Abstract
Physiological and ultrastructural studies of synapses between hippocampal neurons of animals with knock-out of a mammalian actin-binding protein, mAbp1, demonstrated that recycling of synaptic vesicles undergoes, in this case, significant modifications. Thus, mAbp1 is rather important from this aspect, which can be related to the noticeable role of actin in clathrin-mediated endocytosis of synaptic vesicles.
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References
S. Connert, S. Wienand, C. Thiel, et al., “SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport,” EMBO J., 25, 1611–1622 (2006).
S. Sankaranarayanan, D. De Angelis, J. E. Rothman, et al., “The use of pHluorins for optical measurements of presynaptic activity,” Biophys. J., 79, 2199–2208 (2000).
P. Fatt and B. Katz, “Spontaneous subthreshold activity at motor nerve endings,” J. Physiol., 117, 109–128 (1952).
B. Katz, The Release of Neural Transmitter Substances, Liverpool Univ. Press, Liverpool (1969).
B. Zhang, Y. H. Koh, R. B. Beckstead, et al., “Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis,” Neuron, 21, 1465–1475 (1998).
F. Deak, S. Schoch, X. Liu, et al., “Synaptobrevin is essential for fast synaptic-vesicle endocytosis,” Nat. Cell Biol., 6, 1102–1108 (2004).
J. E. Heuser and T. S. Reese, “Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction,” J. Cell Biol., 57, 315–344 (1973).
S. Sankaranarayanan and T. A. Ryan, “Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system,” Nat. Cell Biol., 2, 197–204 (2000).
P. P. Atluri and T. A. Ryan, “The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals,” J. Neurosci., 26, 2313–2320 (2006).
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Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 390–391, July–October, 2007.
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Glyvuk, N., Tsytsyura, Y., Thiel, C. et al. Disturbance of synaptic vesicle recycling resulting from deletion of a mammalian actin-binding protein, mAbp1. Neurophysiology 39, 341–342 (2007). https://doi.org/10.1007/s11062-007-0051-4
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DOI: https://doi.org/10.1007/s11062-007-0051-4