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Increased temperature and acidosis effectively accelerate the recovery of P2X3 receptors from desensitization

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Abstract

Slow recovery from desensitization of P2X3 receptors makes quite problematical understanding of their physiological function. We found that the recovery from desensitization of P2X3 receptors is speeded up by a decrease in external pH and an increase in temperature. On the contrary, the onset of desensitization is independent of these influences. Such unusual combination of temperature sensitivity/insensitivity allows receptors to function near normal body temperature even at low nanomolar concentrations of ATP. Since it is known that slight acidosis and increased temperature are typical of inflammation, we conclude that under inflammatory conditions the function of P2X3 receptors is upregulated.

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References

  1. L. Vulchanova, M. S. Riedl, S. J. Shuster, et al., “P2X3 is expressed by DRG neurons that terminate in inner lamina II,” Eur. J. Neurosci., 10, 3470–3478 (1998).

    Article  PubMed  CAS  Google Scholar 

  2. D. A. Cockayne, S. G. Hamilton, Q. M. Zhu, et al., “Urinary bladder hyporeflexia and reduced pain-related behavior in P2X3-deficient mice,” Nature, 407, 1011–1015 (2000).

    Article  PubMed  CAS  Google Scholar 

  3. V. Souslova, P. Cesare, Y. Ding, et al., “Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors,” Nature, 407, 1015–1017 (2000).

    Article  PubMed  CAS  Google Scholar 

  4. I. Shimizu, T. Iida, Y. Guan, et al., “Enhanced thermal avoidance in mice lacking the ATP receptor P2X3,” Pain, 116, 96–108 (2005).

    Article  PubMed  CAS  Google Scholar 

  5. E. B. Pratt, T. S. Brink, P. Bergson, et al., “Use-dependent inhibition of P2X3 receptors by nanomolar agonist,” J. Neurosci., 25, 7359–7365 (2005).

    Article  PubMed  CAS  Google Scholar 

  6. J. Li, N. C. King, and L. I. Sinoway, “ATP concentrations and muscle tension increase linearly with muscle contraction,” J. Appl. Physiol., 95, 577–583 (2003).

    PubMed  CAS  Google Scholar 

  7. G. Vassort, “Adenosine 5′-triphosphate: a P2-purinergic agonist in the myocardium,” Physiol. Rev., 81, 767–806 (2001).

    PubMed  CAS  Google Scholar 

  8. D. Hille, Ion Channels of Excitable Membranes, Sinauer Associates, Inc., Sunderland, Mass. (2001).

    Google Scholar 

  9. T. Youn, S. A. Kim, and C. M. Hai, “Length-dependent modulation of smooth muscle activation: effects of agonist, cytochalasin, and temperature,” Am. J. Physiol., 274, C1601–C1607 (1998).

    PubMed  CAS  Google Scholar 

  10. Y. Tsuchiya, M. Akashi, and E. Nishida, “Temperature compensation and temperature resetting of circadian rhythms in mammalian cultured fibroblasts,” Genes Cells, 8, 713–720 (2003).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    O. Maximyuk, V. Khmyz & O. Krishtal

  2. International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    O. Maximyuk, V. Khmyz & O. Krishtal

Authors
  1. O. Maximyuk
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  2. V. Khmyz
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  3. O. Krishtal
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Correspondence to O. Maximyuk.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 377–379, July–October, 2007.

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Maximyuk, O., Khmyz, V. & Krishtal, O. Increased temperature and acidosis effectively accelerate the recovery of P2X3 receptors from desensitization. Neurophysiology 39, 330–331 (2007). https://doi.org/10.1007/s11062-007-0046-1

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  • DOI: https://doi.org/10.1007/s11062-007-0046-1

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