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Effect of thapsigargin on inhibitory synaptic transmission between cultured neurons of the rat hippocampus

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Abstract

We carried out electrophysiological experiments on cultured neurons of the rat hippocampus. The voltage-clamp technique and extracellular stimulation of single presynaptic axons were used for measurements of the evoked inhibitory postsynaptic currents (eIPSCs). It was found that 1 µM thapsigargin is capable of modulating inhibitory synaptic transmission, and the effects were ambivalent. Among 21 examined cells, eIPSCs decreased in 15 neurons and were augmented in 6 units; the kinetic parameters of these currents underwent no changes.

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Authors and Affiliations

  1. International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    E. P. Mizerna & N. S. Veselovsky

  2. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    S. A. Fedulova

Authors
  1. E. P. Mizerna
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  2. S. A. Fedulova
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  3. N. S. Veselovsky
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Corresponding author

Correspondence to E. P. Mizerna.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 374–376, July–October, 2007.

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Mizerna, E.P., Fedulova, S.A. & Veselovsky, N.S. Effect of thapsigargin on inhibitory synaptic transmission between cultured neurons of the rat hippocampus. Neurophysiology 39, 327–329 (2007). https://doi.org/10.1007/s11062-007-0045-2

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  • DOI: https://doi.org/10.1007/s11062-007-0045-2

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