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Key role of calcium signaling in synaptic transmission

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Abstract

The review analyzes current concepts on the role of calcium signals in the process of synaptic neuron-to-neuron and neuron-effector transmission and on the respective intracellular mechanisms (participation of different types of ion channels, mitochondria, and endoplasmic reticulum). The involvement of calcium both in the transmission per se, in particular in the process of exocytotic neurotransmitter release, and in long-lasting modulations of the efficacy of synaptic transmission (potentiation or depression) is considered.

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References

  1. B. Katz and R. Miledi, “The timing of calcium action during neuromuscular transmission,” J. Physiol., 189, 535–544 (1967).

    PubMed  CAS  Google Scholar 

  2. P. Kostyuk and A. Verkhratsky, Calcium Signaling in the Nervous System, John Wiley and Sons, Chichester (1985).

    Google Scholar 

  3. S. Thayer and R. Miller, “The calcium concentration in single rat dorsal root ganglion neurons,” J. Physiol., 425, 85–115 (1990).

    PubMed  CAS  Google Scholar 

  4. R. Rizutto, P. Bernardo, and T. Pozzan, “Mitochondria as all-round players of the calcium game,” J. Physiol., 529, 37–47 (2000).

    Article  Google Scholar 

  5. P. Kostyuk, E. Kostyuk, and E. Lukyanetz, Calcium Ions in Nerve Cell Function-from Physiology to Pathology [in Russian], Naukova Dumka, Kyiv (2005).

    Google Scholar 

  6. V. Shishkin, E. Potapenko, E. Kostyuk, et al., “Role of mitochondria in intracellular calcium signaling in primary and secondary neurons,” Cell Calcium, 32, 121–130 (2002).

    Article  PubMed  CAS  Google Scholar 

  7. H. Ishibashi, I.-S. Jang, and J. Nakebura, “High-potassium facilitation of glycine release from presynaptic terminals of mechanically dissociated rat spinal dorsal horn neurons in the absence of extracellular calcium,” Neuroscience, 144, 190–201 (2007).

    Article  Google Scholar 

  8. G. Augustine, “How does calcium trigger neurotransmitter release?” Curr. Opin. Neurobiol., 11, 320–326 (2001).

    Article  PubMed  CAS  Google Scholar 

  9. O. Zaika, O. Pochynyuk, P. Kostyuk, et al., “Acetylcholine-induced calcium signaling in adrenaline-and noradrenaline-containing adrenal chromaffin cells,” Arch. Biochem. Biophys., 424, 25–32 (2004).

    Article  Google Scholar 

  10. R. Gerona, E. Larsen, J. Kowalchyk, and T. Martin, “The C terminus of SNAP25 is essential for calcium-dependent binding of synaptotagmin to SNARE complex,” J. Biol. Chem., 275, 6328–6336 (2000).

    Article  PubMed  CAS  Google Scholar 

  11. J. Szule and J. R. Coorsen, “Revision of the role of SNAREs in exocytosis and membrane fusion,” Biochim. Biophys. Acta, 1641, 121–135 (2003).

    Article  PubMed  CAS  Google Scholar 

  12. L. Voronin, “On the quantal analysis of hippocampal long-term potentiation and related phenomena of synaptic plasticity,” Neuroscience, 56, 275–304 (1993).

    Article  PubMed  CAS  Google Scholar 

  13. I. Levitan and L. Kaczmarek, The Neuron. Cell and Molecular Biology, Oxford Univ. Press, New York, Oxford (2002).

    Google Scholar 

  14. P. D’Alkantra, S. Shifman, and S. Swillens, “Bidirectional synaptic plasticity as a consequence of interdependent Ca2+-controled phosphorylation and dephosphorylation pathways,” Eur. J. Neurosci., 17, 2521–2528 (2003).

    Article  Google Scholar 

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Authors and Affiliations

  1. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    P. G. Kostyuk

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  1. P. G. Kostyuk
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Correspondence to P. G. Kostyuk.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 290–293, July–October, 2007.

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Kostyuk, P.G. Key role of calcium signaling in synaptic transmission. Neurophysiology 39, 248–250 (2007). https://doi.org/10.1007/s11062-007-0034-5

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  • DOI: https://doi.org/10.1007/s11062-007-0034-5

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