Abstract
Under conditions of the open-field test, we demonstrated that bemitil and benzimidazole injected intraperitoneally into rats in doses of 50 to 150 mg/kg suppress horizontal and vertical (motor and research) activities, as well as decrease the frequencies of episodes of grooming, defecation, and urination. Possible mechanisms underlying modifications of behavioral phenomena triggered by the above agents are discussed.
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References
M. A. Rozin, Synthesis of Protein and Resistivity of Cells [in Russian], Nauka, Leningrad (1971).
M. A. Rozin, Pharmacology of Pathological Processes [in Russian], Nauka, Leningrad (1951).
A. A. Spasov, I. N. Iyozhitsa, L I. Bugaeva, et al., “Spectrum of pharmacological activity and toxicological properties of derivatives of benzimidazole,” Khim.-Farm. Zh., 33, No. 5, 6–17 (1999).
G. S. Shaimardanova, R. A. Kamburg, R. P. Evstigneeva, et al., “Imidazole and its derivatives as biologically active substances,” Khim.-Farm. Zh., 8, No. 3, 31–37 (1992).
L. T. Kirichek and Yu. G. Bobkov, “Effect of bemitil on the state of system of self-regulation in short-lasting immobilization,” Farmakol. Toksikol., 54, No. 6, 42–44 (1991).
I. B. Mikhailov, V. I. Guzeva, and M. Ya. Sharf, “Effect of bemitil on experimental seizures,” in.: Bioantioxidant: International Symposium within the Framework of the International Exhibition ‘Medicine and Public Health. Med. Technology and the Drugstore’ (Tyumen’, September 16–19, 1997), Tyumen’ (1997), pp. 174–175.
S. S. Boiko, V. P. Zherdyaev, and G. G. Neznamov, “Role of pharmacokinetics of bemitil in realization of its therapeutic efficiency,” Farmakol. Toksikol., 54, No. 2, 64–66 (1991).
L. I. Bugaeva, A. A. Spasov, V. E. Verovskii, et al., “Study of acute toxicity of bemitil and bromethal,” Éksp. Klin. Farmakol., 63, No. 6, 53–57 (2000).
T. V. Gamma, I. I. Korenyuk, and M. Yu. Baevskii, “Functional state of PPa1 neurons under the action of dibasol and bemitil,” Uch. Zap. Tavrichesk. Nats. Univ., Ser. Biol., Khim., 16 (55), No. 4, 20–27 (2003).
D. A. Kulagin and B. K. Bolondinskii, “Neurochemical aspects of emotional reactivity and motor activity of rats under new conditions,” Usp. Fiziol. Nauk, No. 1, 92–110 (1986).
A. V. Kaluev, Stress, Anxiety, and Behavior [in Russian], Enigma, Kyiv (1998).
A. L. Markel’, “On the estimation of basic characteristics of behavior of rats in the open-field test,” Zh. Vyssh. Nerv. Deyat., 31, No. 2, 301–307 (1981).
A. W. Haefely, “General pharmacology and neuropharmacology of benzodiazepine derivatives,” in: Psychotropic Agents, Part 2: Anxiolytics, Gerontopsycho-pharmacological Agents, and Psychomotor Stimulants, F. Hoffmeister and G. Stille (eds.), Springer-Verlag, Berlin, New York (1981), pp. 60–69.
C. S. Hall, “Emotional behavior in the rat,” J. Comp. Psychol., 18, 385–403 (1936).
J. Bureš, O. Burešova, and J. Hewstone, Technique and Basic Experiments for Studying the Brain and Behavior [Russian translation], Vysshaya Shkola, Moscow (1991).
I. I. Korenyuk, T. V. Gamam, M. Yu. Baevskii, et al., “Effect of bemitil on physiological reaction of rats,” Uch. Zap. Tavrichesk. Nats. Univ., Ser. Biol., Khim., 18 (57), No. 1, 161–166 (2005).
R. I. Kruglikov, V. M. Gertsova, and N. V. Orlova, “Changes in the content of monoamines in the brain influence reaction of emotional resonance,” Zh. Vyssh. Nerv. Deyat., 45, No. 3, 551–557 (1995).
R. I. Kruglikov, N. V. Orlova, and V. M. Gertsova, “Content of noradrenaline and serotonin in symmetrical regions of the rat brain in the norm, in the course of learning, and after injections of peptides,” Zh. Vyssh. Nerv. Deyat., 41, No. 2, 359–363 (1991).
B. I. Khodorov, General Physiology of Excitable Membranes [in Russian], Nauka, Moscow (1975).
V. V. Sachenko and V. I. Khorevin, “Serotonin and central mechanisms underlying motor control,” Neurophysiology, 33, No. 3, 180–196 (2001).
F. Mora, K. F. Sweeney, E. T. Rolls, and A. M. Sanquinetti, “Spontaneous firing rate of neurons in the prefrontal cortex of the rat: evidence for a dopaminergic inhibition,” Brain Res., 116, No. 3, 516–522 (1976).
L. Beani, C. Bianchi, and A. Castekkuccii, “Correlation of brain catecholamines with cortical acetylcholine outflow behavior and electrocorticogram,” Eur. J. Pharmacol., 26, No. 1, 63–72 (1974).
T. V. Gamma, I. I. Korenyuk, M. Yu. Baevsky, et al., “Effects of some benzimidazole derivatives on electrical activity in molluscan neurons,” Neurophysiology, 34, Nos. 2/3, 130–132 (2002).
V. P. Samokhvalov, Evolutionary Psychiatry [in Russian], Dvizheniye, Simferopol’ (1993).
M. E. Celis and E. Torre, “Measurement of grooming behavior,” in: Methods in Neurosciences, A. Conn (ed.), Academic Press, San Diego, New York (1993), pp. 359–378.
A. J. Dunn, C. W. Berrige, and P. Dunshem, “Behavioral tests: their interpretation and significance in the study of peptide action,” in: Neuromethods, A. Boulton, G. Baker, and Q. L. Pittman (eds.), Humana Press, Clifton, New York (1987), pp. 229–247.
E. A. Stone, S. J. Manavalan, Yi. Zhang, and D. Quarterman, “Beta-adrenoreceptor blockade mimics effects of stress on motor activity in mice,” Neuropsychopharmacology, 12, 65–71 (1995).
A. V. Kaluev, Grooming and Stress [in Russian], AVIKS, Moscow (2002).
J. Dewsberi, Behavior of Animals (Comparative Aspects) [Russian translation] Mir, Moscow (1981).
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Neirofiziologiya/Neurophysiology, Vol. 38, No. 1, pp. 85–90, January–February, 2006
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Gamma, T.V., Korenyuk, I.I. Effects of bemitil and benzimidazole on behavior of rats in open-field test. Neurophysiology 38, 75–80 (2006). https://doi.org/10.1007/s11062-006-0028-8
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DOI: https://doi.org/10.1007/s11062-006-0028-8