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Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center

Journal of Neuro-Oncology volume 165, pages 241–250 (2023)Cite this article

Abstract

Purpose

To investigate the efficacy and safety of particle beam radiotherapy (PBRT) in the management of patients with WHO grade 2 and 3 meningiomas.

Methods

Thirty-six consecutive and non-selected patients with WHO grade 2 (n = 28) and grade 3 (n = 8) meningiomas were treated at the Shanghai Proton and Heavy Ion Center, from May 2015 to March 2022. The median age of the cohort at PBRT was 48 years. There were 25 and 11 patients treated with PBRT in the setting of newly diagnosed diseases and progressive/recurrent diseases, respectively. PBRT was utilized as re-irradiation in 5 patients. Proton radiotherapy (PRT) and carbon-ion radiotherapy (CIRT), with a median dose of 60 Gy-Equivalent (GyE), were provided to 30 and 6 patients, respectively.

Results

With a median follow-up of 23.3 months, the local control rates were 92.0%, 82.0%, and 82.0% at 1, 2, and 3 years for the entire cohort, respectively. Patients with WHO grade 2 meningiomas (100%, 94.1%, 94,1% at 1,2,3 years) had a much better local control than those with WHO grade 3 meningiomas (50%, 25%, 25% at 1,2,3 years; P < 0.001). Three patients, all with WHO grade 3 meningiomas, had deceased at the time of this analysis. Multivariate analyses revealed that WHO grade (grade 2 vs. 3) (p = 0.016) was a significant prognosticator for local control. No severe toxicities (G3 or above) were observed.

Conclusions

Treatment-induced efficacy and toxicities to PBRT in WHO grade 2 and 3 meningiomas were both highly acceptable. Longer follow-up is needed to evaluate the long-term outcome in terms of disease control, survival, as well as potential late effects.

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Funding

Shanghai Municipal Health Commission Special Clinical Research Project (Project No.20204Y0281, 202,040,295).

Author information

Authors and Affiliations

  1. Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China

    Xianxin Qiu, Jing Gao, Jiyi Hu, Jing Yang, Weixu Hu, Qingting Huang, Haojiong Zhang & Lin Kong

  2. Department of Radiation Oncology, Huashan Hospital, Fudan University, Shanghai, China

    Xianxin Qiu

  3. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China

    Jing Gao, Jiyi Hu, Jing Yang, Weixu Hu, Qingting Huang & Haojiong Zhang

  4. Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China

    Jing Gao, Jiyi Hu, Jing Yang, Weixu Hu, Qingting Huang, Haojiong Zhang & Lin Kong

  5. Proton and Heavy Ion Center, Heyou International Hospital, Tumor, Guangdong, China

    Jiade J. Lu

  6. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China

    Lin Kong

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  1. Xianxin Qiu
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Contributions

Conception and design: Lin Kong, Jiade J Lu. Acquisition of data: Xianxin Qiu, Jing Gao, Jiyi Hu, Jing Yang, Weixu Hu, Qingting Huang, Haojiong Zhang. Analysis and interpretation of data: Xianxin Qiu, Jing Gao. Drafting or revising the article: Xianxin Qiu, Lin Kong. All authors reviewed the manuscript.

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Correspondence to Lin Kong.

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Qiu, X., Gao, J., Hu, J. et al. Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center. J Neurooncol 165, 241–250 (2023). https://doi.org/10.1007/s11060-023-04401-8

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