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Evaluation of the growth rates and related prognostic factors in radiation-induced meningiomas

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Abstract

Purpose

Literature dedicated to growth patterns and growth rate influencing factors of radiation-induced meningiomas (RIMs) is limited. To deliver new insights into the topic, a volumetric growth analysis of RIMs was performed.

Methods

This single-center, retrospective cohort study included patients diagnosed with intracranial meningioma who received radiation treatment at least > 5 years before the RIM diagnosis. Volumetric analysis of individual RIMs was performed using 3D volumetry at the time of RIM diagnosis and during follow-up. RIM growth was determined by calculating absolute (AGR), and relative (RGR) growth rates. Prognostic factors associated with RIM growth were evaluated.

Results

A total of 26 patients with 33 meningiomas were enrolled in the study and radiologically/clinically followed up during a median duration of 5.6 years (IQR 3.9–8.8 years). Median AGR was 0.19 cm3 per year and the median RGR was 34.5% per year. Surgically managed RIMs were more likely fast-growing compared to observed ones based on the AGR (p < 0.002). The recurrence rate after total resection was 14.3%. Younger age at RIM diagnosis was associated with higher tumor growth (RGR ≥ 30%, p = 0.040). A significant correlation was found between the length of latency period and the RGR (p = 0.005).

Conclusion

To diagnose RIM as early as possible comprehensive MRI surveillance is required. Younger patients with shorter latency periods may profit from shortened MRI intervals, with further management being dependent on the growth rate and eventual symptomatology.

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Data availability

All data generated or analyzed during this study are included in this published article and its supplementary information file.

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Acknowledgements

This study was supported by the Ministry of Health of the Czech Republic - grant no. NU21-07-00419 MH CZ – DRO, University Hospital Motol, Prague, Czech Republic (00064203).

Funding

This study was supported by the Ministry of Health of the Czech Republic - grant no. NU21-07-00419 MH CZ – DRO, University Hospital Motol, Prague, Czech Republic (00064203).

Author information

Author notes

  1. Christian Joachim Entenmann and Adéla Bubeníková contributed equally and share first authorship.

Authors and Affiliations

  1. Department of Neurosurgery, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

    Christian Joachim Entenmann, Adéla Bubeníková, Jana Blažková Jr., Ondřej Bradáč & Vladimír Beneš 3rd

  2. Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic

    Adéla Bubeníková & Ondřej Bradáč

  3. Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

    Michal Zápotocký, Jarmila Kruseová, David Sumerauer, Kateřina Trková & Vladimíra Sochová

  4. Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

    Miroslav Koblížek

  5. Department of Radiology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

    Martin Kynčl

  6. Department of Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

    Běla Malinová

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  1. Christian Joachim Entenmann
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Contributions

Conceptualization: Vladimír Beneš 3rd; Methodology: Vladimír Beneš 3rd, Ondřej Bradáč, Christian Joachim Entenmann, Adéla Bubeníková; Data acquisition: Christian Joachim Entenmann, Vladimír Beneš 3rd; Formal analysis and investigation: Adéla Bubeníková, Ondřej Bradáč; Writing – original draft preparation: Christian Joachim Entenmann, Adéla Bubeníková; Writing review and editing: all authors listed; Supervision: Ondřej Bradáč, Vladimír Beneš 3rd.

Corresponding author

Correspondence to Christian Joachim Entenmann.

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The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

Ethical approval was waived by the local Ethics Committee of the Second Faculty of Medicine, Charles University and University Hospital Motol in view of the retrospective nature of the study and all the procedures being performed were part of the routine care.

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Entenmann, C.J., Bubeníková, A., Blažková, J. et al. Evaluation of the growth rates and related prognostic factors in radiation-induced meningiomas. J Neurooncol 161, 155–163 (2023). https://doi.org/10.1007/s11060-022-04209-y

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