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Lactate dehydrogenase as promising marker for prognosis of brain metastasis

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Abstract

Background

Lactate dehydrogenase (LDH) is a biomarker for cancer. However, the relationship between serum LDH levels and the survival of patients with brain metastasis has been fully revealed. We aimed to evaluate the serum LDH levels and assess its prognostic value in patients with BM.

Methods

The serum LDH levels were collected from 2507 patients with BM. Patients were categorized into four groups according to the quartile of serum LDH levels. The association between serum LDH levels and overall survival (OS) was evaluated using Cox regression models and Kaplan–Meier curves. Three predictive models were used to evaluate patients.

Results

The Kaplan–Meier curve for survival by the serum LDH group demonstrates clear separation between four groups (P < 0.001). The participants in the lower group had longer OS than those in the higher group. After adjusting in multivariate Cox regression models remained significant for patients in the Q4 compared with patients in the Q1 (Q4:Q1 OR 1.58, 95% CI 1.38–1.80). Furthermore, the GPA-LDH model generates a pooled area under the curve of 0.630 (95% CI 0.600, 0.660).

Conclusions

Serum LDH levels and OS in patients with brain metastasis is an inverse association. Moreover, Serum LDH levels can improve the prognosis of the GPA model.

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Acknowledgements

None.

Funding

The work was supported by National Natural Science Foundation of China (Grant Nos. 82172842, and 81803104 and 81672386), the Sichuan Province Science and Technology Support Program (Grant Nos. 2021YFSY008, 2020YFS0276), West China Nursing Discipline Development Special Fund Project (Grant No. HXHL21008), the Technology Innovation Project of Chengdu Science and Technology Bureau (Grant No. 2019-YF05-00459-SN), Postdoctoral research and Development Fund and Translational medicine fund of West China Hospital (Grant Nos. 2020HXBH119 and CGZH19002, National Key R&D Program of China (2018YFA0108604), the 1·3·5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (21HXFH046), the innovation team project of Affiliated Hospital of Clinical Medicine College of Chengdu University (CDFYCX202203), the project of Sichuan Science and Technology Bureau (22ZDYF0798), and Clinical Incubation Program of West China Hospital, SCU（2018HXFU008). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. Yi-Yan Pei and Yu Zhang contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China

    Yi-Yan Pei, Zhe-Ran Liu, Yan He, Jing-Jing Wang & Xing-Chen Peng

  2. Department of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China

    Yu Zhang

  3. School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

    Jia-Yi Yu

  4. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Ren-Jie Zhang & Fang Fang

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  1. Yi-Yan Pei
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Contributions

FF and XCP conceived the study and designed the protocol. YYP, YH, and JYY collected data and cleaned data. YYP, YZ and ZRL analyzed and interpret data. YYP and YZ wrote the first draft of the paper. FF, XCP, YYP, YZ, ZRL, YH, JYY, RJZ, and JJW critically revised successive drafts of the paper and approved the final version. FF and XCP are the guarantors of the review.

Corresponding authors

Correspondence to Xing-Chen Peng or Fang Fang.

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The author declare that they have no competing interest.

Ethical approval

The study was approved by Ethics Committee on Biomedical Research West China Hospital of Sichuan University. The study was performed in accordance with the Declaration of Helsinki.

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Pei, YY., Zhang, Y., Liu, ZR. et al. Lactate dehydrogenase as promising marker for prognosis of brain metastasis. J Neurooncol 159, 359–368 (2022). https://doi.org/10.1007/s11060-022-04070-z

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