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The role of stereotactic radiosurgery in the management of petroclival meningioma: a systematic review

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Abstract

Purpose: Petroclival meningioma (PM) is a challenging neuro oncology case and stereotactic radiosurgery (SRS) is proposed as one treatment option. This systematic review aimed to examine the role of SRS in treating PM cases. Methods: We constructed a systematic review using the PRISMA guidelines using peer-reviewed English literature until 16 February 2022 from EuroPMC and PubMed. We used the terms petroclival meningioma, clival meningioma, apex petrous meningioma, spheno petroclival meningioma, stereotactic radiosurgery, radiosurgery, CyberKnife, Gamma Knife, linear accelerator, LINAC, and radiotherapy. Results: 10 out of 266 studies were chosen for this systematic review, two of which are case reports. The study comprised 719 patients, 73.7% of whom were female (n = 530) and had a median age of 56.99 years (18–90 years). At the time of diagnosis, the median tumor volume was 6.07 cm3 (0.13–64.9 cm3). The tumors were frequently located near the petroclival junction (83.6%, n = 598). Following SRS, the median follow-up was 64.52 months (3–252 months). 46.5% of 719 PMs exhibited a decrease in tumor size. 46% and 7.5% showed no change and increase in tumor volume, respectively. At the last radiographic follow-up (7–21.2 years), tumor control with a median of 98.8% (85–100%). Complications occurred in 6% of patients, with hydrocephalus (2.2%) as the prevalent complication. The use of SRS as a primary treatment for petroclival cases was not associated with increased complication rate RR 0.62 (95% CI [0.11, 3.59], p = 0.59) but statistically correlated with clinical failure clinical failure RR 0.56 (95% CI [0.32, 0.98], p = 0.04). Conclusions: We found a low number of complications following SRS intervention and has been effectively controlling tumor progression.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

PM:

Petroclival meningioma

SRS:

Stereotactic radiosurgery

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-analyses

JBI:

Joanna Briggs Institute’s

NOS:

Newcastle–Ottawa Scale

CNS:

Central nervous system

M:

Male

F:

Female

Gy:

Gray

VP:

Ventriculoperitoneal

CN:

Cranial nerve

nr:

Not reported

NA:

Not applicable

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia

    Jeremiah Hilkiah Wijaya, Yang Yang Endro Arjuna & Julius July

  2. Department of Neurosurgery, Universitas Pelita Harapan, Tangerang, Banten, Indonesia

    Julius July

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  1. Jeremiah Hilkiah Wijaya
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JHW, YEA, and JJ. The first draft of the manuscript was written by JHW and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jeremiah Hilkiah Wijaya.

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Wijaya, J.H., Arjuna, Y.E. & July, J. The role of stereotactic radiosurgery in the management of petroclival meningioma: a systematic review. J Neurooncol 159, 33–42 (2022). https://doi.org/10.1007/s11060-022-04041-4

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