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Psychosocial profiles of risk and resiliency in neurofibromatoses: a person-centered analysis of illness adaptation

  • Clinical Study
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Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Objectives

We sought to characterize psychosocial profiles of adaptation to neurofibromatosis (NF).

Methods

Participants (N = 224) completed self-report measures of psychosocial functioning, including risk (i.e., perceived stress, depression, anxiety) and resiliency (i.e., gratitude, optimism, coping, social support, mindfulness, empathy). We used a TwoStep hierarchical cluster analysis to determine clusters reflecting adaptation to NF.

Results

The analysis revealed two distinct groups, with the “Low Adaptation” group defined by high emotional distress and low resiliency (n = 130; 57% of participants), and the “High Adaptation” group defined by low emotional distress and high resiliency (n = 85; 37% of participants). Clusters differed significantly across nearly all criterion variables, as well as quality of life and pain interference.

Conclusion

Both risk and resiliency factors are important for understanding psychosocial adaptation to NF. Findings suggest that clinical providers should prioritize screening and intervention methods targeting these variables to promote positive adaptation to NF.

Trial registration

ClinicalTrials.gov NCT03406208; https://clinicaltrials.gov/ct2/show/NCT03406208 (Archived by WebCite at http://www.webcitation.org/72ZoTDQ6h).

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Data availability

The data described in this study are available from the corresponding author upon reasonable request.

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Funding

Funding was provided by U.S. Department of Defense (Grant No. W81XWH-17-1-0121).

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Author notes

  1. Sarah M. Bannon and Sarah W. Hopkins have contributed equally to this work.

Authors and Affiliations

  1. Integrated Brain Health Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square Suite 100, Boston, MA, USA

    Sarah M. Bannon, Sarah W. Hopkins, Victoria A. Grunberg & Ana-Maria Vranceanu

Authors
  1. Sarah M. Bannon
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  2. Sarah W. Hopkins
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  3. Victoria A. Grunberg
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  4. Ana-Maria Vranceanu
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Contributions

SB led the literature review, conceptual design, and manuscript preparation. SH developed the analytic framework and data analyses. VG supported conceptual design, data analyses, and manuscript preparation. A-MV supervised and guided manuscript preparation and editing of review findings.

Corresponding author

Correspondence to Ana-Maria Vranceanu.

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The authors declare no conflicts of interest.

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Bannon, S.M., Hopkins, S.W., Grunberg, V.A. et al. Psychosocial profiles of risk and resiliency in neurofibromatoses: a person-centered analysis of illness adaptation. J Neurooncol 156, 519–527 (2022). https://doi.org/10.1007/s11060-021-03928-y

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  • DOI: https://doi.org/10.1007/s11060-021-03928-y

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