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Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma

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Abstract

Purpose

Meningiomas are the most common intracranial tumors, accounting for 20–30% of central nervous system tumors. Recently, the European Medicines Agency issued an alert on cyproterone acetate (CPA) based on the results of a study that found an increased risk of meningioma 7 to 20 times higher when a patient is on CPA.

The primary objective of this study was to determine the prevalence of CPA exposure in patients who had one or more intracranial meningiomas treated surgically or with radiation therapy. The secondary objectives were to establish a description of the patients who had intracranial meningioma in Nantes and to establish whether there was a difference in the intrinsic and tumoral characteristics of patients exposed to CPA compared with patients who had no hormonal exposure and patients who had been exposed to other hormones.

Methods

Monocentric, retrospective study including all patients treated by surgery or radiotherapy for intracranial meningioma from 2014 to 2017 excluding those with a history of exposure to ionizing radiation or neurofibromatosis type 2.

Results

388 patients were included, 277 were treated by surgery and 111 by radiotherapy. 3.9% of the patients had a history or current use of CPA, 16.2% were taking other hormonal treatment. Compared with the group without hormonal exposure, the CPA-exposed group had significantly an earlier onset of meningiomas at 48.9 vs. 61.9 years (p = 0.0005) and had more multiple meningiomas, 26.7% vs. 6.1% (p = 0.0115).

Conclusions

In our study, patients with a history or current use of CPA had significantly more meningiomas and were significantly younger at the onset.

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Acknowledgements

We thank Mr Peter Tucker for English language editing.

Author information

Author notes

  1. Edouard Samarut and Alexandre Lugat have equally contributed to this manuscript.

  2. Delphine Drui and Vincent Roualdes have equally contributed to this manuscript.

Authors and Affiliations

  1. Neurotraumatology, Neurosurgery Department, Hotel-Dieu, CHU Nantes, Nantes, France

    Edouard Samarut, Kevin Buffenoir & Vincent Roualdes

  2. L’institut du thorax, Endocrinology, Diabetology and Nutrition Department, CHU Nantes, Nantes, France

    Alexandre Lugat, Emeric Scharbarg, Samy Hadjadj, Bertrand Cariou & Delphine Drui

  3. Inserm UMR 1232, CRCINA, Université d’Angers, Université de Nantes, Nantes, France

    Alexandre Lugat

  4. Neurosurgery Department, Bretonneau Hospital, CHRU Tours, Tours, France

    Aymeric Amelot

  5. Inserm UMR 1253, Université de Tours, Tours, France

    Aymeric Amelot

  6. Inserm UMR 1413, CIC, Endocrinology, Diabetology and Nutrition, CHU Nantes, Nantes, France

    Claire Primot

  7. Pathology Department, Hotel-Dieu, CHU Nantes, Nantes, France

    Delphine Loussouarn

  8. Radiotherapy Department, Institut de Cancérologie de l’Ouest (ICO), Saint-Herblain, France

    François Thillays

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Contributions

ES and AL: collected the data, contributed in data analysis and interpretation and drafted the manuscript. AL, AA, ES and SH performed statistical analysis. DL performed the pathological analysis. FT contributed in data collection. DD and VR conceived and designed the analysis. All authors performed a critical revision of the manuscript and significantly contributed to the final version. All authors approved the final manuscript.

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Correspondence to Delphine Drui or Vincent Roualdes.

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The local ethics committee (GNEDS: Groupe Nantais d’Ethique dans le Domaine de la Santé) approved the collection and use of this data (approval on November 12, 2018).

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Samarut, E., Lugat, A., Amelot, A. et al. Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma. J Neurooncol 152, 115–123 (2021). https://doi.org/10.1007/s11060-020-03683-6

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  • DOI: https://doi.org/10.1007/s11060-020-03683-6

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