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Pediatric meningiomas: 10-year experience with 39 patients

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Abstract

Objective

The purpose of this article was to study the characteristics of pediatric meningiomas, including the clinical symptom, anatomic location, radiological finding, treatment approaches, and long-term surgical outcome as well as the possible influence factors of the prognosis.

Methods

We retrospectively reviewed the medical records and follow-up data of 39 pediatric patients who were treated by operation for intracranial meningiomas in West-China Hospital between 2009–2019.

Results

The incidence of pediatric meningioma was 0.74%. The mean age at surgery was 12.2 years and the ratio of male to female was 1.3. Three cases (7.7%) were related to neurofibromas. WHO grade I was found in 26 patients (66.7%) and higher grades was seen in 13 (33.3%). The most common location sites were convexity (35.9%). Gross total excision was achieved in 28 patients (71.8%). The mean follow-up period was 54.4 months. The recurrence rate was 41.9%. By survival analysis, only gross total resection (p = 0.028) was associated with favorable outcome.

Conclusion

Meningiomas in children are very rare and have a slight male predominance. Pediatric meningiomas are more commonly located in intraventricular and have higher incidence rate of high-grade than that in adults. Although being challenging, the gross total excision should be underdone to achieve a better prognosis.

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Acknowledgements

We thank the radiologists who helped us evaluate the radiological imaging parameters of all the tumors. This work is supported by key research and development project of science and technology department of Sichuan Province (Grant No. 2019YFS0392/3) and 1.3.5 Project for disciplines of excellence, West China Hospital, Sichuan University (Grant No. ZYJC18007).

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Author notes

  1. Wenbo He and Zhiyong Liu have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China

    Wenbo He, Zhiyong Liu, Haibo Teng & Jianguo Xu

  2. West China School of Medicine, Sichuan University, Chengdu, 610041, China

    Wenbo He, Haibo Teng, Liansha Tang, Danyang Jie, Zonghao Duan & Heye Yu

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  1. Wenbo He
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Contributions

Conception and design: JX, WH, ZL. Acquisition of data: WH, HT, DJ, LT, HY, ZD. Analysis and interpretation of data: WH, LT, HT. Drafting the article: WH. Critically revising the article: ZL. Reviewed submitted version of manuscript: JX. Approved the final version of the manuscript on behalf of all authors: JX.

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Correspondence to Jianguo Xu.

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The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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He, W., Liu, Z., Teng, H. et al. Pediatric meningiomas: 10-year experience with 39 patients. J Neurooncol 149, 543–553 (2020). https://doi.org/10.1007/s11060-020-03649-8

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