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Prospective memory and brain metastases: a relevant target for rehabilitation in post-operative patients?

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Abstract

Purpose

The study investigated the prospective memory (PM) functioning among patients with brain metastases (BM), eligible for neurosurgy/radiosurgery, and its relationships with depression and quality of life (QoL).

Methods

This case-healthy-control, cross-sectional study, comprised 160 participants, including 49 patients with BM from various cancers treated with neurosurgery or radiosurgery. They were compared with 111 matched controls on a set of neuropsychological tests, including the MoCA global cognitive test and an experimental PM task ‘PROMESSE’. Participants also completed a depression scale (BDI-II), a generic (SF-12) and a specific (QLQ-C30) QoL instrument for cancer patients. Multivariate analyses were conducted on various PM outcomes, in particular on event-based (EBPM) and time-based (TBPM) PM performances.

Results

After adjusting for age and socio-cultural level, patients with BM performed worse than the control on the PM task (p < .0001) [OR 1.05; 95%CI (1.01–1.08)], whatever the location of BM (frontal versus temporal lobe). Patients with infratentorial BM exhibited better TBPM performances than patients with supratentorial BM (p = .02). The global PM performance was positively correlated with the MoCA (r = .45) and the SF-12 global score (r = .34), and negatively with the BDI-II score (r = − .20), the number of BM (r = − .34) and the volumetric of the BM (r = − 29). The TBPM performance was linked to the global QoL (r = .40) in patients.

Conclusion

The study showed a significant PM deficit in patients with BM eligible for a neurosurgy/radiosurgery, which is linked to damaged QoL and which likely maintains some depressive affects. Prospective memory rehabilitation program should especially focus on TBPM for post-operative patients with BM.

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Acknowledgements

This study was supported by the SIRIC Montpellier Cancer (Grant INCa_Inserm_DGOS_12553). The authors sincerely thank the participants for their time. They are grateful to the neurosurgery staff, the clinical research assistants (Vanessa Gros and Mathieu Merlot), Emmanuel Vigliano for his help in computer design, Marry Harries for her assistance in English, and Pr. Marc Ychou and Dr. Pierre Senesse for their SIRIC support.

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Authors and Affiliations

  1. Department of Supportive Care, Montpellier Cancer Institute (ICM) – University of Montpellier, 208 avenue des Apothicaires, 34298, Montpellier, France

    Estelle Guerdoux-Ninot & Grégory Ninot

  2. Department of Neurosurgery, Montpellier University Hospital - INSERM U1051, Montpellier, France

    Luc Bauchet & François-Yves Legninda Sop

  3. Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy

    François-Yves Legninda Sop & Grégory Ninot

  4. Neurosurgery Unit, Fondazione Policlinico Universitario “A. Gemelli”, Rome, Italy

    François-Yves Legninda Sop

  5. Department of Biometrics, Montpellier Cancer Institute (ICM) – University of Montpellier, Montpellier, France

    Sophie Gourgou

  6. Laboratory Epsylon EA 4556, University of Montpellier, Montpellier, France

    Adeline Gomez & Aurélie Gerazime

  7. Department of Medical Oncology, Montpellier Cancer Institute (ICM) – University of Montpellier, Montpellier, France

    Amélie Darlix

Authors
  1. Estelle Guerdoux-Ninot
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  2. Luc Bauchet
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  3. François-Yves Legninda Sop
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  8. Grégory Ninot
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Correspondence to Estelle Guerdoux-Ninot.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Guerdoux-Ninot, E., Bauchet, L., Legninda Sop, FY. et al. Prospective memory and brain metastases: a relevant target for rehabilitation in post-operative patients?. J Neurooncol 147, 185–194 (2020). https://doi.org/10.1007/s11060-020-03414-x

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  • DOI: https://doi.org/10.1007/s11060-020-03414-x

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