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Initial biopsy and early re-resection practices in the treatment of glioblastoma among AANS/CNS tumor section surgeons

  • Clinical Study
  • Published:
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Abstract

Introduction

Surgical management strategies for glioblastoma (GBM) may differ among neurosurgeons with initial biopsy of suspected tumors and the need for early re-resection of tumors within 30 days of initial surgery. This study was initiated by the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) Tumor Section’s interest in understanding the rates at which pre- and post-resection procedures, specifically biopsies prior to definitive resection and early re-resections, are performed by U.S. neurosurgeons in the management of GBM.

Methods

A ten-question survey was distributed to members of the AANS/CNS Tumor Section.

Results

The survey response rate among AANS/CNS Tumor Section surgeons was approximately 16%. Results showed that a majority of respondents performed surgery on 11–25 GBM cases annually. Of those cases, most neurosurgeons claimed that biopsies are rarely performed prior to tumor resection, but in the < 10% of cases for which biopsies are done, common reasons are to confirm radiological findings or improve the treatment plan. Likewise, re-resections are rare, but in the < 5 cases most neurosurgeons performed annually, common reasons included incomplete initial resections, referrals for greater resection, or unspecified reasons.

Conclusions

Further studies are needed to confirm the results of this study, which shows low rates of stereotactic and open biopsy and early re-resection procedures performed among neurosurgeons. These rates may help form guidelines in the treatment of GBM and encourage the use of surgical adjuncts that increase the extent of resection of these tumors, thereby reducing rates of early recurrence.

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Funding

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Authors and Affiliations

  1. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Rebecca B. Baron, Remi A. Kessler & Constantinos G. Hadjipanayis

  2. Department of Neurosurgery, Mount Sinai Union Square, New York, NY, USA

    Constantinos G. Hadjipanayis

Authors
  1. Rebecca B. Baron
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  2. Remi A. Kessler
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  3. Constantinos G. Hadjipanayis
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Contributions

Manuscript writing, data analysis, and figure generation—RBB, Development of survey and data collection—RAK, Development and oversight of survey and manuscript—CGH.

Corresponding author

Correspondence to Rebecca B. Baron.

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Conflicts of interest

RBB has no disclosures to report. RAK has no disclosures to report. Constantinos Hadjipanayis is a consultant for NX Development Corp. (NXDC) and Synaptive Medical Inc. He receives royalties from NXDC.

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Baron, R.B., Kessler, R.A. & Hadjipanayis, C.G. Initial biopsy and early re-resection practices in the treatment of glioblastoma among AANS/CNS tumor section surgeons. J Neurooncol 144, 529–534 (2019). https://doi.org/10.1007/s11060-019-03253-5

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  • DOI: https://doi.org/10.1007/s11060-019-03253-5

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