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Growth rate and fate of untreated hemangioblastomas: clinical assessment of the experience of a single institution

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Abstract

Background

The growth rate and natural history of untreated hemangioblastomas remain unclear. This study investigated the natural history of untreated intracranial hemangioblastomas and predictors of tumor growth using volumetric assessment.

Method

This study retrospectively enrolled 31 patients with untreated hemangioblastomas between 2004 and 2017 who were followed up for at least 12 months. The 31 patients had a total of 52 hemangioblastomas.

Results

The 31 patients included 11 (35.5%) men and 20 (64.5%) women, of mean age 42.5 years. Seventeen (54.8%) patients were genetically diagnosed with Von Hippel-Lindau (VHL) disease. Of the 52 lesions, 33 (63.5%) grew during the follow-up period, whereas 19 (36.5%) remained stable. Overall mean actual growth rate (AGR) was 1.94 cm3/year, 2.38 cm3/year in the VHL and 1.79 cm3/year in the non-VHL group (p = 0.31). Overall mean relative growth rate (RGR) was 21%/year, 26%/year in the VHL and 19%/year in the non-VHL group. Time to 50% treatment probability was 34 months. The 1, 3, 5, and 7-year treatment probabilities were 11.5%, 50.1%, 52.7%, and 73%, respectively. The presence of only symptomatic lesions was significantly predictive of the growth of intracranial hemangioblastoma (odds ratio: 5.0, p = 0.02).

Conclusion

The overall growth rate of intracranial hemangioblastoma was faster than that of other benign intracranial tumors, with symptomatic lesions being the only meaningful predictor of tumor growth. Because of their rapid growth rate and high probability of treatment, a wait and scan management strategy should be carefully applied to intracranial hemangioblastomas.

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References

  1. Neumann HPH, Eggert HR, Weigel Klaus, Friedburg H, Wiestler OD, Schollmeyer P (1989) Hemangioblastomas of the central nervous system A 10-year study with special reference to von Hippel-Lindau syndrome. J Neurosurg 70:24–30

    Article  CAS  PubMed  Google Scholar 

  2. Bridgesa KJ, Jaboinb JJ, Kubicky CD, Thana KD (2017) Stereotactic radiosurgery versus surgical resection for spinalhemangioblastoma: a systematic review. Clin Neurol Neurosurg 154:59–66

    Article  Google Scholar 

  3. Kano H, Shuto T, Iwai Y, Sheehan J, Yamamoto M, McBride HL, Sato M, Serizawa T, Yomo S, Moriki A, Kohda Y, Young B, Suzuki S, Kenai H, Duma C, Kikuchi Y, Mathieu D, Akabane A, Nagano O, Kondziolka D, Lunsford LD (2015) Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study. J Neurosurg 122:1469–1478

    Article  PubMed  Google Scholar 

  4. Roberti F, Jones RV, Wright DC (2007) Cranial nerve hemangioblastomas. Report of a rare case and review of literature. Surg Neurol 67:640–646

    Article  PubMed  Google Scholar 

  5. Wan J-Q, Cui H, Wang Y (2011) Surgical management of large solid hemangioblastomas of the posterior fossa. J Clin Neurosci 18:39–42

    Article  PubMed  Google Scholar 

  6. Fukuda M, Takao T, Hiraishi T, Yoshimura J, Yajima N, Saito A, Fujii Y (2014) Clinical factors predicting outcomes after surgical resection for sporadic cerebellar hemangioblastomas. World Neurosurg 82:815–821

    Article  PubMed  Google Scholar 

  7. Liu X, Zhang Y, Hui X, You C, Yuan F, Chen W, Zhang S (2015) Surgical management of medulla oblongata hemangioblastomas in one institution: an analysis of 62 cases. Int J Clin Exp Med 8:5576–5590

    PubMed  PubMed Central  Google Scholar 

  8. Cheng J, Liu W, Zhang S, Lei D, Hui X (2017) Clinical features and surgical outcomes in patients with cerebellopontine angle hemangioblastomas: retrospective series of 23 cases. World Neurosurg 103:248–256

    Article  PubMed  Google Scholar 

  9. Cui H, Zou J, Bao YH, Wang MS, Wang Y (2017) Surgical treatment of solid hemangioblastomas of the posterior fossa: a report of 28 cases. Oncol Lett 13:1125–1130

    Article  PubMed  Google Scholar 

  10. Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT (2010) Treatment decision making based on the published natural history and growth rate of small meningiomas. J Neurosurg 113:1036–1042

    Article  PubMed  Google Scholar 

  11. Lee EJ, Kim JH, Park ES, Kim Y-H, Lee JK, Hong SH, Cho YH, Kim CJ (2017) A novel weighted scoring system for estimating the risk of rapid growth in untreated intracranial meningiomas. J Neurosurg 127:971–980

    Article  PubMed  Google Scholar 

  12. Nguyen HS, Doan NB, Gelsomino M, Shabani S, Awad AJ, Kaushal M, Mortazavi MM (2018) Intracranial hemangioblastoma—a SEER-based analysis 2004–2013. Oncotarget 9:28009–28015

    PubMed  PubMed Central  Google Scholar 

  13. Wanebo JE, Lonser RR, Glenn GM, Oldfield EH (2003) The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease. J Neurosurg 98:82–94

    Article  PubMed  Google Scholar 

  14. Lonser RR, Butman JA, Huntoon K, Asthagiri AR, Wu T, KnD Bakhtian, Chew EY, Zhuang Z, Linehan WM, Oldfield EH (2014) Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease. J Neurosurg 120:1055–1062

    Article  PubMed  PubMed Central  Google Scholar 

  15. Ammerman JM, Lonser RR, Dambrosia J, Butman JA, Oldfield EH (2006) Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment. J Neurosurg 105:248–255

    Article  PubMed  Google Scholar 

  16. Peyre M, David P, Effenterre RV, François P, Thys M, Emery E, Redondo A, Decq P, Aghakhani N, Parker F, Tadié M, Lacroix C, Bhangoo R, Giraud S, Richard S (2010) Natural history of supratentorial hemangioblastomas in von Hippel-Lindau disease. Neurosurgery 67:577–587. https://doi.org/10.1227/01.NEU.0000374846.86409.A7

    Article  PubMed  Google Scholar 

  17. Paldor I, Chen AS, Kaye AH (2016) Growth rate of vestibular schwannoma. J Clin Neuroscience 32:1–8

    Article  Google Scholar 

  18. Firsching RP, Fischer A, Peters R, Thun F, Klug N (1990) Growth rate of incidental meningiomas. J Neurosurg 73:545–547

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors thank the referring physicians and the neuroradiologists and pathologists of our institution. We also thank Na Young Kim, a statistician in our institute, who performed the statistical analysis and assisted in the writing of the Methods section of this report.

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Correspondence to Jeong Hoon Kim.

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The authors declare no competing interests in relation to this study.

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Byun, J., Yoo, H.J., Kim, J.H. et al. Growth rate and fate of untreated hemangioblastomas: clinical assessment of the experience of a single institution. J Neurooncol 144, 147–154 (2019). https://doi.org/10.1007/s11060-019-03213-z

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