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Smoking status and perioperative adverse events in patients undergoing cranial tumor surgery

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Introduction

Smoking is agreed to be a major health risk factor, but it is debated whether it has an influence on perioperative adverse events (AEs) in elective cranial tumor surgery.

Methods

We analyzed the 2013–2016 data from our prospective institutional patient registry. Consecutive patients undergoing elective microsurgical tumor surgery of a glioma or a meningioma were included. Patients were categorized as active smokers, former smokers, and non-smokers. AE were graded by the therapy-oriented Clavien–Dindo scale. Possible predictors of postoperative AE were identified with the help of a binomial logistic regression model.

Results

We identified 798 patients, out of which 480 were non-smokers, 193 active smokers, and 125 former smokers. The rate of AEs for active smokers (30%, 95% CI [23–37%]) was indistinguishable from the AE rate of non-smokers (32%, 95% CI [28–37%]). No difference between smoking status was found looking at all AE individually, the odds ratio of suffering from local AE and systemic AE respectively were the same between all smoking groups. The modified Rankin scale at hospital admission was a strong and significant predictor of postoperative AE (P = 0.013).

Conclusions

Active smoking was not associated with an increased risk for postoperative AE, neither looking at the total number of AE nor looking at individual AE. Smoking status should therefore not be a major factor in preoperative decision making. Although not based on data of this study, doctors should always encourage patients to stop smoking due to its well-known detrimental health effect.

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Abbreviations

AE:

Adverse event

CDG:

Clavien–Dindo grading system

mRS:

Modified Rankin scale

KPS:

Karnofsky performance scale

LOS:

Length of stay

BMI:

Body-mass-index

OR:

Odds ratio

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland

    Luis Padevit, Johannes Sarnthein, Martin Nikolaus Stienen, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli & Marian Christoph Neidert

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  1. Luis Padevit
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Correspondence to Marian Christoph Neidert.

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Padevit, L., Sarnthein, J., Stienen, M.N. et al. Smoking status and perioperative adverse events in patients undergoing cranial tumor surgery. J Neurooncol 144, 97–105 (2019). https://doi.org/10.1007/s11060-019-03206-y

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