Journal of Neuro-Oncology

, Volume 138, Issue 3, pp 659–666 | Cite as

Molecular profiles for insular low-grade gliomas with putamen involvement

  • Chunyao Zhou
  • Yongheng Wang
  • Xing Liu
  • Yuchao Liang
  • Ziwen Fan
  • Tao Jiang
  • Yinyan Wang
  • Lei Wang
Clinical Study



The newly proposed putamen classification system shows good prognostic value in patients with insular LGGs, yet no study towards the molecular profiles of putamen involved LGGs has been proposed.


Clinical information and imaging data of patients diagnosed with insular low-grade gliomas were collected retrospectively. Genetic information of the 34 tumors was assessed using RNA-sequencing. Gene set enrichment analysis was further performed to identify the genes showing differential expression between putamen-involved tumors and putamen non-involved tumors. The level of Ki-67 expression was also evaluated.


There were 843 genes identified to be differentially expressed between putamen-involved and non-involved gliomas. Specifically, Gene set enrichment analysis discovered 13 Kyoto Encyclopedia of Genes and Genomes pathways and 37 Gene Ontology Biological Process term were upregulated in putamen-involved low-grade glioma cells. The enriched GO sets with the highest gene counts included cell cycle (42 genes), mitotic cell cycle (24 genes), and cell division (19 genes). Furthermore, high expression of Ki-67 was associated with putamen involvement in insular gliomas.


There is clear genetic variation between putamen-involved and non-involved insular low-grade gliomas. The differential expression of genes related to the processes of cell proliferation, cell migration, or DNA repair may lead to putamen involvement. The findings suggest that among the two subtypes, putamen-involved insular low-grade gliomas have higher malignancy, and the clinical treatment towards the putamen-involved insular low-grade gliomas should be more active.


Insular glioma Molecular profile Genomic feature Putamen Prognosis 



This work was supported by National Basic Research Program of China (No. 2015CB755500), National Natural Science Foundation of China (No. 81601452), Beijing Natural Science Foundation (No. 7174295) and Key science and technology research project of the Hebei provincial health and Family Planning Commission (No. 20171258).

Compliance with ethical standards

Conflict of interest

We report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Ethical approval

This retrospective study was approved by the institutional review board of Beijing Tiantan hospital, written consent was obtained from all of our enrolled patients.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery, Beijing Tiantan HospitalCapital Medical UniversityBeijingChina
  2. 2.Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina
  3. 3.Department of NeurosurgeryQinhuangdao First HospitalHebeiChina
  4. 4.Center of Brain TumorBeijing Institute for Brain DisordersBeijingChina

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