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Potential use of prostate specific membrane antigen (PSMA) for detecting the tumor neovasculature of brain tumors by PET imaging with 89Zr-Df-IAB2M anti-PSMA minibody

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Abstract

Tumor angiogenesis has attracted increasing attention because of its potential as a valuable marker in the differential diagnosis of brain tumors as well as a novel therapeutic target. Prostate-specific membrane antigen (PSMA) is expressed by the neovasculature endothelium of some tumors, with little to no expression by the tumor cells or normal vasculature endothelium. The aim of this study was to investigate the potential of PSMA for the evaluation of the tumor neovasculature of various brain tumors and the possibility of detecting PSMA expression in brain tumors using PET imaging with 89Zr-Df-IAB2M (anti-PSMA minibody). Eighty-three tissue specimens including gliomas, metastatic brain tumors, primary central nervous system lymphomas (PCNSL), or radiation necroses were analyzed by immunohistochemical staining with PSMA antibody. 89Zr-Df-IAB2M PET scans were performed in three patients with recurrent high-grade gliomas or metastatic brain tumor. PSMA was highly expressed in the vascular endothelium of high-grade glioma and metastatic brain tumor, whereas PSMA was poorly expressed in the vascular endothelium of PCNSL and radiation necrosis. PSMA expression in high-grade gliomas and a metastatic brain tumor was clearly visualized by PET imaging with 89Zr-Df-IAB2M. Furthermore, a trend toward a positive correlation between the degree of 89Zr-Df-IAB2M uptake and PSMA expression levels in tumor specimens was observed. PET imaging of PSMA using 89Zr-Df-IAB2M may have potential value in the differential diagnosis of high-grade glioma from PCNSL or radiation necrosis as well as in the prediction of treatment efficacy and assessment of treatment response to bevacizumab therapy for high-grade glioma.

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Acknowledgements

We wish to thank the members of the Tsukuba Clinical Research & Development Organization (T-CReDO) for their critical advice in conducting the study and data management during the study period. We would like to thank the members of the Tsukuba Molecular Imaging Center for carrying out PET imaging.

Funding

Research funding was provided by grants from ImaginAb (Los Angeles, CA, USA) and the University of Tsukuba Hospital. ImaginAb also covered manufacturing and shipment costs of 89Zr-Df-IAB2M.

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Authors and Affiliations

  1. Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan

    Masahide Matsuda, Eiichi Ishikawa, Tetsuya Yamamoto, Yosuke Masuda & Akira Matsumura

  2. Department of Applied Molecular Imaging, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Kentaro Hatano

  3. Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Akira Joraku & Hiroyuki Nishiyama

  4. Tsukuba Clinical Research & Development Organization, University of Tsukuba Hospital, Tsukuba, Japan

    Yuichi Iizumi

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  1. Masahide Matsuda
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  2. Eiichi Ishikawa
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Correspondence to Masahide Matsuda.

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Matsuda, M., Ishikawa, E., Yamamoto, T. et al. Potential use of prostate specific membrane antigen (PSMA) for detecting the tumor neovasculature of brain tumors by PET imaging with 89Zr-Df-IAB2M anti-PSMA minibody. J Neurooncol 138, 581–589 (2018). https://doi.org/10.1007/s11060-018-2825-5

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  • DOI: https://doi.org/10.1007/s11060-018-2825-5

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