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A surgical strategy using a fusion image constructed from 11C-methionine PET, 18F-FDG-PET and MRI for glioma with no or minimum contrast enhancement

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Abstract

The objective of this study was to investigate the distribution of 11C-methionine (MET) and F-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) imaging and the hyperintense area in T2 weighted imaging (T2WI) in glioma with no or poor gadolinium enhancement in magnetic resonance imaging (GdMRI). Cases were also analyzed pathologically. We prospectively investigated 16 patients with non- or minimally enhancing (< 10% volume) glioma. All patients underwent MET-PET and FDG-PET scans preoperatively. After delineating the tumor based on MET uptake, integrated 3D images from FDG-PET and MRI (GdMRI, T2WI or FLAIR) were generated and the final resection plane was planned. This resection plane was determined intraoperatively using the navigation-guided fencepost method. The delineation obtained by MET-PET imaging was larger than that with GdMRI in all cases with an enhanced effect. In contrast, the T2WI-abnormal signal area (T2WI+) tended to be larger than the MET uptake area (MET+). Tumor resection was > 95% in the non-eloquent area in 4/5 cases (80%), whereas 10 of 11 cases (90.9%) had partial resection in the eloquent area. In a case including the language area, 92% resection was achieved based on the MET-uptake area, in contrast to T2WI-based partial resection (65%), because the T2WI+/MET− area defined the language area. Pathological findings showed that the T2WI+/MET+ area is glioma, whereas 6 of 9 T2WI+/MET− lesions included normal tissues. Tissue from T2W1+/MET+/FDG+/GdMRI+ lesions gave an accurate diagnosis of grade in six cases. Non- or minimally enhancing gliomas were classified as having a MET uptake area that totally or partially overlapped with the T2WI hyperintense area. Resection planning with or without a metabolically active area in non- or minimally enhancing gliomas may be useful for accurate diagnosis, malignancy grading, and particularly for eloquent area although further study is needed to analyze the T2WI+/MET− area.

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Authors and Affiliations

  1. Department of Neurosurgery, Ube-kohsan Central Hospital Corporation, 750 Nishikiwa, Ube, Yamaguchi, 755-0151, Japan

    Makoto Ideguchi, Takafumi Nishizaki, Norio Ikeda, Tomomi Okamura, Yasue Tanaka, Natsumi Fujii, Machiko Ohno & Taichi Shimabukuro

  2. Department of Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan

    Tokuhiro Kimura & Eiji Ikeda

  3. The Department of Radiology, St. Hill Hospital, Ube, Japan

    Kazuyoshi Suga

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  1. Makoto Ideguchi
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  2. Takafumi Nishizaki
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Correspondence to Makoto Ideguchi.

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Ideguchi, M., Nishizaki, T., Ikeda, N. et al. A surgical strategy using a fusion image constructed from 11C-methionine PET, 18F-FDG-PET and MRI for glioma with no or minimum contrast enhancement. J Neurooncol 138, 537–548 (2018). https://doi.org/10.1007/s11060-018-2821-9

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