AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway
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As an important member of the Annexins, AnnexinA5 has been attributed important functions in trophoblast membrane repair, anticoagulation and cellular signal transduction. Accumulated studies show that AnnexinA5 is closely associated with various types of carcinomas. However, the potential contribution of AnnexinA5 to glioma cancer progression remains unclear. In this study, we report that AnnexinA5 is significantly upregulated in both high-grade glioma samples and glioma cell lines. Moreover, overexpression of AnnexinA5 promotes cell migration and invasion in vitro and tumorigenicity of glioma cells in nude mice, while knockdown of AnnexinA5 manifests a repressive function during these cellular processes. Importantly, mechanistic studies further reveal that AnnexinA5 is an essential transcriptional target of Snail via activating the PI3K/Akt/NF-κB signaling pathway. Taken together, these findings suggest that AnnexinA5 or the PI3K/Akt/NF-κB pathway may be promising therapeutic molecules to eradicate glioma metastases.
KeywordsGlioma AnnexinA5 PI3K/Akt/NF-Κb Progression Signaling pathway
This work was supported by the National Scientific Foundation of China grants (No. 81560411).
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
This study was approved by the Review Board at The Second Affiliated Hospital of Nanchang University, and written informed consent was obtained from each participant. All procedures performed were in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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