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5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

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Abstract

Introduction

5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.

Methods

Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.

Results

We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.

Conclusions

The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

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Funding

This study was funded by National Institutes of Health (US) Grant No. R01 NS052274 (D.W. Roberts).

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Authors and Affiliations

  1. Department of Neurosurgery, Harvard Medical School/Brigham and Women’s Hospital, 60 Fenwood Road, Boston, MA, 02115, USA

    Pablo A. Valdes

  2. Department of Neurosurgery, Medical University of Vienna, Wahringer Gurtel 18-20, Vienna, Austria

    Matthias Millesi & Georg Widhalm

  3. Department of Neurosurgery, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA

    David W. Roberts

Authors
  1. Pablo A. Valdes
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  2. Matthias Millesi
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  3. Georg Widhalm
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  4. David W. Roberts
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Corresponding author

Correspondence to Pablo A. Valdes.

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Conflict of interest

D.W. Roberts and P.A. Valdes have multiple patents for intraoperative fluorescence imaging devices noted in this manuscript. D.W. Roberts has equity in InSight Surgical Technologies LLC. M. Millesi and G. Widhalm report no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Valdes, P.A., Millesi, M., Widhalm, G. et al. 5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery. J Neurooncol 141, 555–565 (2019). https://doi.org/10.1007/s11060-018-03079-7

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  • DOI: https://doi.org/10.1007/s11060-018-03079-7

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