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SNF5 as a prognostic factor in skull base chordoma

  • Clinical Study
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Abstract

The current study aimed to characterize SNF5 expression and investigate the relationship between SNF5 and clinicopathological features in skull base chordoma. 48 patients diagnosed with skull base chordoma were enrolled in this study. Tissue microarray and immunohistochemistry were performed to evaluate the expression of SNF5 in skull base chordoma. Kaplan–Meier survival analysis was used to assess survival. Multivariable Cox regression analysis was used to identify risk factors affecting patient survival. The H-scores for cytoplasmic SNF5 ranged from 124.47 to 254.52. Low expression of SNF5 was correlated with shorter overall survival (OS) (p = 0.021). Patients with age > 55 years old had shorter progression free survival (PFS) and OS times than patients whose age ≤ 55 years old (p = 0.005 and 0.003, respectively). The gross total resection group showed longer PFS than the non-gross total resection group (p = 0.024). Females showed shorter PFS times than males (p = 0.033). Multivariable Cox regression analysis showed that age, extent of resection and sex were independent prognostic factors for PFS (p = 0.010, 0.013 and 0.042, respectively). Age was an independent prognostic factor for OS (p = 0.010). Our study indicate that low expression of SNF5 is associated with poor prognosis in skull base chordoma.

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Abbreviations

OS:

Overall survival

PFS:

Progression free survival

TMA:

Tissue microarray

ATP:

Adenosine triphosphate

EIF4E:

Eukaryotic initiation factor 4E

HR:

Hazard ratio

CI:

Confidence interval

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Acknowledgements

The study was supported by the Research Special Fund For Public Welfare Industry of Health (201402008); Supported by the National High Technology Research and Development Program of China (863 Program); Supported by the National Natural Science Foundation of China (30971005).

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    Authors and Affiliations

    1. Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

      Mingxuan Li, Yixuan Zhai, Shuai Wang, Hua Gao, Chuzhong Li & Yazhuo Zhang

    2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

      Jiwei Bai, Songbai Gui & Yazhuo Zhang

    3. Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

      Jiang Du

    4. Beijing Institute for Brain Disorders Brain Tumor Center, Beijing, China

      Yazhuo Zhang

    5. China National Clinical Research Center for Neurological Diseases, Beijing, China

      Yazhuo Zhang

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    1. Mingxuan Li
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    Drs. Mingxuan Li and Yixuan Zhai have contributed equally to this work.

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    Li, M., Zhai, Y., Bai, J. et al. SNF5 as a prognostic factor in skull base chordoma. J Neurooncol 137, 139–146 (2018). https://doi.org/10.1007/s11060-017-2706-3

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