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Journal of Neuro-Oncology

, Volume 135, Issue 2, pp 419–421 | Cite as

Extraneuraxial metastases in medulloblastoma: is histology and molecular biology important?

  • Tejpal Gupta
  • Archya Dasgupta
  • Sridhar Epari
  • Neelam Shirsat
  • Girish Chinnaswamy
  • Rakesh Jalali
Letter to the Editor

To the Editor,

Novel biological insights in medulloblastoma have recently led to its consensus classification [1] into four distinct molecular subgroups (WNT, SHH, group 3, and group 4). Although relatively rare, it is widely accepted that medulloblastomas have a higher propensity of spread outside the neuraxis compared to other central nervous system (CNS) tumors with a reported frequency of extraneuraxial metastases (ENM) ranging from 2 to 5% [2]. We herein report a single-institutional cohort of patients with ENM from medulloblastoma with reference to histological subtyping and molecular subgrouping.

Electronic search of the prospective institutional neuro-oncology database identified a total of 573 patients with histological diagnosis of medulloblastoma registered at our institute between 2005 and 2016. Of these, 300 patients had also undergone molecular subgrouping as part of an Institutional Review Board (IRB) approved research study. Molecular subgroup assignment was based on...

Notes

Funding

No financial support was involved in preparation of this manuscript.

Compliance with ethical standards

Conflict of interest

None of the authors have any conflict of interest to declare.

Ethical approval

The study was duly approved by the Institutional Ethics Committee (IEC) that granted waiver of consent in view of retrospective nature of the study.

References

  1. 1.
    Taylor M, Northcott P, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123:465–472CrossRefPubMedGoogle Scholar
  2. 2.
    Paulino AC (2012) Extraneural metastasis in medulloblastoma. In M.A. Hyatt (ed) Tumors of the central nervous system, vol 8. Springer, New York, pp 71–75Google Scholar
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    Kunder R, Jalali R, Sridhar E et al (2013) Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin fixed paraffin embedded medulloblastomas. Neuro-Oncol 15(12):1644–1651CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Young R, Khakoo Y, Yhu S et al (2015) Extraneural metastases of medulloblastoma: desmoplastic variants may have prolonged survival. Pediatr Blood Cancer 62:611–615CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Departments of Radiation Oncology(TMH and ACTREC), Tata Memorial CentreNavi MumbaiIndia
  2. 2.Departments of Pathology(TMH and ACTREC), Tata Memorial CentreNavi MumbaiIndia
  3. 3.Neuro-Oncology LabACTREC, Tata Memorial CentreNavi MumbaiIndia
  4. 4.Departments of Pediatric Medical Oncology(TMH and ACTREC), Tata Memorial CentreNavi MumbaiIndia

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