Extraneuraxial metastases in medulloblastoma: is histology and molecular biology important?
To the Editor,
Novel biological insights in medulloblastoma have recently led to its consensus classification  into four distinct molecular subgroups (WNT, SHH, group 3, and group 4). Although relatively rare, it is widely accepted that medulloblastomas have a higher propensity of spread outside the neuraxis compared to other central nervous system (CNS) tumors with a reported frequency of extraneuraxial metastases (ENM) ranging from 2 to 5% . We herein report a single-institutional cohort of patients with ENM from medulloblastoma with reference to histological subtyping and molecular subgrouping.
Electronic search of the prospective institutional neuro-oncology database identified a total of 573 patients with histological diagnosis of medulloblastoma registered at our institute between 2005 and 2016. Of these, 300 patients had also undergone molecular subgrouping as part of an Institutional Review Board (IRB) approved research study. Molecular subgroup assignment was based on...
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Conflict of interest
None of the authors have any conflict of interest to declare.
The study was duly approved by the Institutional Ethics Committee (IEC) that granted waiver of consent in view of retrospective nature of the study.
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