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Diffuse midline skull base meningiomas: identification of a rare and aggressive subgroup of meningiomas

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Abstract

Skull base meningiomas may present as clinically aggressive tumors despite being histologically benign. Here we describe a clinico-radiological entity of diffuse midline skull base meningiomas responsible for several neurological morbidities, including hearing and vision loss, intracranial hypertension, secondary hydrocephalus and tonsillar herniation with spinal cord compression. Surgery and radiotherapy were ineffective in stopping the clinical course of those tumors. After targeted sequencing of known mutated genes in meningiomas, we discovered TRAF7 mutations in two out of four tumors, stressing the importance of focusing the research efforts of the meningioma community in understanding the mechanisms underlying TRAF7 related meningioma tumorigenesis.

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Acknowledgements

We thank the iGenSeq Genotyping and Sequencing Core facility at the ICM Brain and Spine Institute for their help in DNA sequencing.

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Authors and Affiliations

  1. Department of Neurosurgery, Groupe Hospitalier Pitié-Salpêtrière, APHP, 47-83 boulevard de l’Hôpital, Batiment Babinski, 75013, Paris, France

    Matthieu Peyre, Soledad Navarro, Anne-Laure Boch & Michel Kalamarides

  2. Université Paris VI – Pierre et Marie Curie, Paris, France

    Matthieu Peyre, Loïc Feuvret, Marc Sanson, Soledad Navarro, Anne-Laure Boch & Michel Kalamarides

  3. Department of Radiotherapy, Groupe Hospitalier Pitié-Salpêtrière, APHP, Paris, France

    Loïc Feuvret

  4. Department of Neuro-Oncology, Groupe Hospitalier Pitié-Salpêtrière, APHP, Paris, France

    Marc Sanson

  5. TUCERA Network, Bordeaux, France

    Hugues Loiseau

Authors
  1. Matthieu Peyre
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  2. Loïc Feuvret
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  3. Marc Sanson
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  4. Soledad Navarro
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  5. Anne-Laure Boch
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  6. Hugues Loiseau
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  7. Michel Kalamarides
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Corresponding author

Correspondence to Matthieu Peyre.

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The authors declare that they have no personal conflicts of interest and no institutional financial interest in any drugs, materials, or devices described in this manuscript.

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Peyre, M., Feuvret, L., Sanson, M. et al. Diffuse midline skull base meningiomas: identification of a rare and aggressive subgroup of meningiomas. J Neurooncol 133, 633–639 (2017). https://doi.org/10.1007/s11060-017-2480-2

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  • DOI: https://doi.org/10.1007/s11060-017-2480-2

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