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Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma

Journal of Neuro-Oncology volume 132, pages 351–358 (2017)Cite this article

Abstract

Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data from 2001 to 2011 draws from 28% of the U.S. population. Latinos have a lower incidence of GBM and present slightly younger than non-Latino Whites. Cubans present at an older age than other Latino sub-populations. Latinos have a higher incidence of giant cell glioblastoma than non-Latino Whites while the incidence of gliosarcoma is similar. Despite lower rates of radiation therapy and greater rates of sub-total resection than non-Latino Whites, Latinos have better 1 and 5 year survival rates. SEER does not record chemotherapy data. Survivals of Latino sub-populations are similar with each other. Age, extent of resection, and the use of radiation therapy are associated with improved survival but none of these variables are sufficient in a multivariate analysis to explain the improved survival of Latinos relative to non-Latino Whites. As molecular data is not available in SEER records, we studied the MGMT and IDH status of 571 patients from a UCLA database. MGMT methylation and IDH1 mutation rates are not statistically significantly different between non-Latino Whites and Latinos. For UCLA patients with available information, chemotherapy and radiation rates are similar for non-Latino White and Latino patients, but the latter have lower rates of gross total resection and present at a younger age.

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References

  1. American Cancer Society (2016) Brain and spinal cord tumors in adults. http://www.cancer.org/cancer/braincnstumorsinadults/detailedguide/brain-and-spinal-cord-tumors-in-adults-key-statistics. Accessed 22 Apr 2016

  2. CBTRUS (2012), CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2008 (March 23, 2012 Revision). Source: central brain tumor registry of the United States, Hinsdale, IL

  3. Braganza MZ, Kitahara CM, de González AB et al (2012) Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review. Neuro Oncol 14(11):1316–1324

    Article  Google Scholar 

  4. Neglia JP, Robison LL, Stovall M et al (2006) New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Inst 98(21):1528–1537

    Article  Google Scholar 

  5. Krishnan G, Felini M, Carozza SE et al (2003) Occupation and adult gliomas in the San Francisco bay area. J Occup Environ Med 45(6):639–647

    Article  Google Scholar 

  6. Savitz DA, Loomis DP (1995) Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141(2):123–134

    CAS  Article  Google Scholar 

  7. Greig NH, Ries LG, Yancik R et al (1990) Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 82(20):1621–1624

    CAS  Article  Google Scholar 

  8. Hess KR, Broglio KR, Bondy ML (2004) Adult glioma incidence trends in the United States, 1977–2000. Cancer 101(10):2293–2299

    Article  Google Scholar 

  9. Chandler KL, Prados MD, Malec M et al (1993) Long-term survival in patients with glioblastoma multiforme. Neurosurgery 32(5):716–720

    CAS  Article  Google Scholar 

  10. Müller H, Brock M, Ernst H (1985) Long-term survival and recurrence-free interval in combined surgical, radio and chemotherapy of malignant brain gliomas. Clin Neurol Neurosurg 87(3):167–171

    Article  Google Scholar 

  11. Salford LG, Brun A, Nirfalk S (1988) Ten-year survival among patients with supratentorial astrocytomas grade III and IV. J Neurosurg 69(4):506–509

    CAS  Article  Google Scholar 

  12. Thumma SR, Fairbanks RK, Lamoreaux WT et al (2012) Effect of pretreatment clinical factors on overall survival in glioblastoma multiforme: A surveillance epidemiology and end results (SEER) population analysis. World J Surg Oncol 10:75

    Article  Google Scholar 

  13. Stupp R, Hegi ME, Mason WP et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466

    CAS  Article  Google Scholar 

  14. Weathers SP, Gilbert MR (2014) Advances in treating glioblastoma. F1000Prime Rep 2;6:46. doi:10.12703/P646

    Article  Google Scholar 

  15. Kamoshima Y, Motegi H, Terasaka S et al (2012) Analyses of IDH1 mutation and MGMT promoter methylation status for 5 cases of long-term survivors with glioblastoma. No Shinkei Geka 40(2):129–135

    CAS  PubMed  Google Scholar 

  16. Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997–1003

    CAS  Article  Google Scholar 

  17. Preston-Martin S (1989) Descriptive epidemiology of primary tumors of the brain cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 8(6):283–295

    CAS  Article  Google Scholar 

  18. Robertson JT, Gunter BC, Somes GW (2002) Racial differences in the incidence of gliomas: a retrospective study from Memphis, Tennessee. Br J Neurosurg 16(6):562–566

    CAS  Article  Google Scholar 

  19. Barnholtz-Sloan JS, Maldonado JL, Williams VL et al (2007) Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neuro-Oncol 85(2):171–180

    Article  Google Scholar 

  20. Deorah S, Lynch CF, Sibenaller ZA et al (2006) Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20(4):E1

    Article  Google Scholar 

  21. Chakrabarti I, Cockburn M, Cozen W et al (2005) A population-based description of glioblastoma multiforme in Los Angeles County, 1974–1999. Cancer 104(12):2798–2806

    Article  Google Scholar 

  22. Colby SL, Ortman JM (2015) Projections of the size and composition of the U.S. population: 2014 to 2060 population, estimates and projections current population: U.S. department of commerce economics and statistics administration, U.S. census bureau, census.gov, P25–1143

  23. Curry WT Jr, Barker FG 2nd (2009) Racial, ethnic and socioeconomic disparities in the treatment of brain tumors. J Neurooncol 93(1):25–39

    Article  Google Scholar 

  24. Murthy VH, Krumholz HM (2004) Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 291(22):2720–2726

    CAS  Article  Google Scholar 

  25. NAACCR Race and Ethnicity Work Group. (2009) NAACCR guideline for enhancing hispanic/latino identification: revised NAACCR hispanic/latino identification algorithm [NHIA v2.2]. North American Association of Central Cancer Registries, Springfield

  26. McLendon RE, Robinson JS Jr, Chambers DB et al (1985) The glioblastoma multiforme in Georgia, 1977–1981. Cancer 56(4):894–897

    CAS  Article  Google Scholar 

  27. Barnholtz-Sloan JS, Sloan AE, Schwartz AG (2003) Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973–1997. J Neurosurg 99(3):458–466

    Article  Google Scholar 

  28. Dubrow R, Darefsky AS (2011) Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007. BMC Cancer 11:325

    Article  Google Scholar 

  29. Brown M, Schrot R, Bauer K et al (2009) Incidence of first primary central nervous system tumors in California, 2001–2005: children, adolescents and teens. J Neuro-Oncol 94(2):263–273

    Article  Google Scholar 

  30. Koshy M, Villano JL, Dolecek TA et al (2012) Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neuroonco 107(1): 207–212

    Article  Google Scholar 

  31. Burger PC, Green SB (1987) Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59(9):1617–1625

    CAS  Article  Google Scholar 

  32. Sneed PK, Prados MD, McDermott MW et al (1995) Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost. Neurosurgery 36(5):898–903

    CAS  Article  Google Scholar 

  33. Krex D, Klink B, Hartmann C et al (2007) Long-term survival with glioblastoma multiforme. Brain 130(Pt 10):2596–2606

    Article  Google Scholar 

  34. Laws ER, Parney IF, Huang W et al (2003) Glioma outcomes investigators. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the glioma outcomes project. J Neurosurg 99(3):467–473

    Article  Google Scholar 

  35. Simpson JR, Horton J, Scott C et al (1993) Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26(2):239–244

    CAS  Article  Google Scholar 

  36. Lacroix M, Abi-Said D, Fourney DR et al (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):1908

    Article  Google Scholar 

  37. Singal V, Singal AK, Kuo YF (2012) Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis. J Cancer Res Clin Oncol 138(4):715–722

    Article  Google Scholar 

  38. McCann J, Artinian V, Duhaime L et al (2005) Evaluation of the causes for racial disparity in surgical treatment of early stage lung cancer. Chest 128(5):3440–3446

    Article  Google Scholar 

  39. Terplan M, Schluterman N, McNamara EJ et al (2012) Have racial disparities in ovarian cancer increased over time? An analysis of SEER data. Gynecol Oncol 125(1):19–24

    Article  Google Scholar 

  40. Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5(10):1725–1731

    CAS  Article  Google Scholar 

  41. Stupp R, Dietrich PY, Kraljevic SO et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20(5):1375–1382

    CAS  Article  Google Scholar 

  42. Aizer AA, Ancukiewicz M, Nguyen PL et al (2014) Underutilization of radiation therapy in patients with glioblastoma: predictive factors and outcomes. Cancer 120(2):238–243

    Article  Google Scholar 

  43. Walker GV, Li J, Mahajan A et al (2012) Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme: a population-based analysis. Cancer 118(18):4538–4544

    Article  Google Scholar 

  44. Punglia RS, Weeks JC, Neville BA et al (2006) Effect of distance to radiation treatment facility on use of radiation therapy after mastectomy in elderly women. Int J Radiat Oncol Biol Phys 66(1):56–63

    Article  Google Scholar 

  45. Bradley CJ, Given CW, Roberts C (2002) Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst 94(7):490–496

    Article  Google Scholar 

  46. Kozak KR, Moody JS (2009) Giant cell glioblastoma: a glioblastoma subtype with distinct epidemiology and superior prognosis. Neuro Oncol 11(6):833–841

    Article  Google Scholar 

  47. Wang T, Jani A, Saad S et al (2014) RT-36 Oncologic outcome of Hispanic patients with glioblastoma treated with radiotherapy. Neuro-Oncol 16(Suppl 5):v195. doi:10.1093/neuonc/nou270.32

    Article  PubMed Central  Google Scholar 

  48. Lopez-Gonzalez MA, Sotelo J (2000) Brain tumors in Mexico: characteristics and prognosis of glioblastoma. Surg Neurol 53(2):157–162

    CAS  Article  Google Scholar 

  49. National Cancer Institute Surveillance, Epidemiology, End Result Program (2016) Number of persons by race and hispanic ethnicity for SEER participants. http://seer.cancer.gov/registries/data.html. Accessed 09 Aug 2016

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Acknowledgements

This work was supported by the Art of the Brain Foundation and Henry E. Singleton Cancer Fund.

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    Affiliations

    1. Divison of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 LeConte Avenue, CHS13-145B, 90095, Los Angeles, CA, USA

      Maryam Shabihkhani, Masoud Movassaghi, Yalda B. Naeini, Seyed Amin Hojat, Diviya Gupta, Gregory M. Lucey, Michael Ontiveros, Michael W. Wang, Lauren S. Hanna, Desiree E. Sanchez, Sergey Mareninov, Negar Khanlou, Harry V. Vinters & William H. Yong

    2. Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA

      Donatello Telesca

    3. Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

      Kourosh M. Naeini

    4. Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

      Harry V. Vinters, Phioanh Leia Nghiemphu, Albert Lai & Timothy F. Cloughesy

    5. Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

      Marvin Bergsneider & Linda M. Liau

    6. Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA

      Marvin Bergsneider, Albert Lai, Linda M. Liau, Timothy F. Cloughesy & William H. Yong

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    1. Maryam Shabihkhani
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    Correspondence to William H. Yong.

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    Maryam Shabihkhani and Donatello Telesca have contributed equally.

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    Shabihkhani, M., Telesca, D., Movassaghi, M. et al. Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma. J Neurooncol 132, 351–358 (2017). https://doi.org/10.1007/s11060-017-2377-0

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    Keywords

    • Glioblastoma
    • Hispanic
    • Latino
    • Ethnicity
    • Race
    • Giant cell glioblastoma