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Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004–2012, varying)

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Abstract

Cancer registries are an important source of population-level information on brain tumor incidence and survival. Surveillance, Epidemiology, and End Results (SEER) registries currently collect data on specific required factors related to brain tumors as defined by the American Joint Commission on Cancer, including World Health Organization (WHO) grade, MGMT methylation and 1p/19q codeletion status. We assessed ‘completeness’, defined as having valid values over the time periods that they have been collected, overall, by year, histology, and registry. Data were obtained through a SEER custom data request for four factors related to brain tumors for the years 2004–2012 (3/4 factors were collected only from 2010 to 2012). SEER*Stat was used to generate frequencies of ‘completeness’ for each factor overall, and by year, histology and registry. The four factors varied in completeness, but increased over time. WHO grade has been collected the longest, and showed significant increases in completeness. Completeness of MGMT and 1p/19q codeletion was highest for glioma subtypes for which testing is recommended by clinical practice guidelines. Completeness of all factors varied by histology and cancer registry. Overall, several of the factors had high completeness, and all increased in completeness over time. With increasing focus on ‘precision medicine’ and the incorporation of molecular parameters into the 2016 WHO CNS tumor classification, it is critical that the data are complete, and factors collected at the population level are fully integrated into cancer reporting. It is critical that cancer registries continue to collect established and emerging prognostic and predictive factors.

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Funding

QTO, HG, and JSB-S were supported by the National Cancer Institute Case Comprehensive Cancer Center Support Grant (P30CA043703). CBTRUS is honored to be included among the research grant recipients of the following organizations, which have contributed to the maintenance of the CBTRUS database: the Centers for Disease Control and Prevention (CDC) under Agreement 5U58DP00383, the Sontag Foundation, Genentech, Novocure, Inc., Celldex Therapeutics, Inc., AbbVie, Inc., along with the Musella Foundation, Voices Against Brain Cancer, Elekta, the Zelda Dorin Memorial Fund, as well as private and in kind donations.

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Authors and Affiliations

  1. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Wearn 152, Cleveland, OH, 44106, USA

    Quinn T. Ostrom, Haley Gittleman & Jill S. Barnholtz-Sloan

  2. Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, IL, USA

    Quinn T. Ostrom, Haley Gittleman, Carol Kruchko & Jill S. Barnholtz-Sloan

  3. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    David N. Louis

  4. Department of Pathology and Laboratory Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Daniel J. Brat

  5. Neuro-Oncology Branch, National Institutes of Health, Bethesda, MD, USA

    Mark R. Gilbert

  6. Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA

    Valentina I. Petkov

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Quinn T. Ostrom and Haley Gittleman: share first authorship.

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Ostrom, Q.T., Gittleman, H., Kruchko, C. et al. Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004–2012, varying). J Neurooncol 130, 31–42 (2016). https://doi.org/10.1007/s11060-016-2217-7

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