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Advanced MRI may complement histological diagnosis of lower grade gliomas and help in predicting survival

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Abstract

MRI grading of grade II and III gliomas may have an important impact on treatment decisions. Occasionally, both conventional MRI (cMRI) and histology fail to clearly establish the tumour grade. Three cMRI features (no necrosis; no relevant oedema; absent or faint contrast enhancement) previously validated in 196 patients with supratentorial gliomas directed our selection of 68 suspected low-grade gliomas (LGG) that were also investigated by advanced MRI (aMRI), including perfusion weighted imaging (PWI), diffusion weighted imaging (DWI) and spectroscopy. All the gliomas had histopathological diagnoses. Sensitivity and specificity of cMRI pre-operative diagnosis were 78.5 and 38.5 %, respectively, and 85.7 and 53.8 % when aMRI was included, respectively. ROC analysis showed that cut-off values of 1.29 for maximum rCBV, 1.69 for minimum rADC, 2.1 for rCho/Cr ratio could differentiate between LGG and HGG with a sensitivity of 61.5, 53.8, and 53.8 % and a specificity of 54.7, 43 and 64.3 %, respectively. A significantly longer OS was observed in patients with a maximum rCBV <1.46 and minimum rADC >1.69 (80 vs 55 months, p = 0.01; 80 vs 51 months, p = 0.002, respectively). This result was also confirmed when cases were stratified according to pathology (LGG vs HGG). The ability of aMRI to differentiate between LGG and HGG and to predict survival improved as the number of aMRI techniques considered increased. In a selected population of suspected LGG, classification by cMRI underestimated the actual fraction of HGG. aMRI slightly increased the diagnostic accuracy compared to histopathology. However, DWI and PWI were prognostic markers independent of histological grade.

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Acknowledgments

This work was supported by funding from the Associazione Italiana per la Ricerca sul Cancro (AIRC) to G. Filippini and from the Italian Ministry of Health to G. Finocchiaro. We wish to thank Valter Torri and Greta Brenna for their statistical support.

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Authors and Affiliations

  1. Unit of Neuro-Radiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    Valeria Cuccarini, A. Erbetta, F. Ghielmetti, M. Grisoli & M. G. Bruzzone

  2. Unit of Neuro-Epidemiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    M. Farinotti & G. Filippini

  3. Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    L. Cuppini, G. Finocchiaro & M. Eoli

  4. Unit of Neuro-Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    B. Pollo

  5. Unit of Neuro-Surgery I, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    F. Di Meco

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  1. Valeria Cuccarini
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  2. A. Erbetta
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Correspondence to Valeria Cuccarini.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Cuccarini, V., Erbetta, A., Farinotti, M. et al. Advanced MRI may complement histological diagnosis of lower grade gliomas and help in predicting survival. J Neurooncol 126, 279–288 (2016). https://doi.org/10.1007/s11060-015-1960-5

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