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Location of brain tumor intersecting white matter tracts predicts patient prognosis

  • Clinical Study
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Abstract

Brain tumor cells invade adjacent normal brain along white matter (WM) bundles of axons. We therefore hypothesized that the location of tumor intersecting WM tracts would be associated with differing survival. This study introduces a method, voxel-wise survival analysis (VSA), to determine the relationship between the location of brain tumor intersecting WM tracts and patient prognosis. 113 primary glioblastoma (GBM) patients were retrospectively analyzed for this study. Patient specific tumor location, defined by contrast-enhancement, was combined with diffusion tensor imaging derived tractography to determine the location of axons intersecting tumor enhancement (AXITEs). VSA was then used to determine the relationship between the AXITE location and patient survival. Tumors intersecting the right anterior thalamic radiation (ATR), right inferior fronto-occipital fasciculus (IFOF), right and left cortico-spinal tract (CST), and corpus callosum (CC) were associated with decreased overall survival. Tumors intersecting the CST, body of the CC, right ATR, posterior IFOF, and inferior longitudinal fasciculus are associated with decreased progression-free survival (PFS), while tumors intersecting the right genu of the CC and anterior IFOF are associated with increased PFS. Patients with tumors intersecting the ATR, IFOF, CST, or CC had significantly improved survival prognosis if they were additionally treated with bevacizumab. This study demonstrates the usefulness of VSA by locating AXITEs associated with poor prognosis in GBM patients. This information should be included in patient-physician conversations, therapeutic strategy, and clinical trial design.

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Abbreviations

VSA:

Voxel-wise survival analysis

AXITE:

Axons intersecting tumor enhancement

WM:

White matter

OS:

Overall survival

PFS:

Progression free survival

ATR:

Anterior thalamic radiation

IFOF:

Inferior fronto-occipital fasciculus

CST:

Cortico-spinal tract

CC:

Corpus callosum

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Funding

Advancing a Healthier Wisconsin, and the MCW Cancer Center.

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Authors and Affiliations

  1. Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA

    Nikolai J. Mickevicius, Kathleen M. Schmainda & Peter S. LaViolette

  2. Department of Radiology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA

    Alexander B. Carle, Trevor Bluemel, Stephanie Santarriaga, Kathleen M. Schmainda & Peter S. LaViolette

  3. Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA

    Fallon Schloemer, Derrick Shumate & Jennifer Connelly

Authors
  1. Nikolai J. Mickevicius
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  2. Alexander B. Carle
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  3. Trevor Bluemel
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  4. Stephanie Santarriaga
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  9. Peter S. LaViolette
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Correspondence to Peter S. LaViolette.

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Mickevicius, N.J., Carle, A.B., Bluemel, T. et al. Location of brain tumor intersecting white matter tracts predicts patient prognosis. J Neurooncol 125, 393–400 (2015). https://doi.org/10.1007/s11060-015-1928-5

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  • DOI: https://doi.org/10.1007/s11060-015-1928-5

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