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Where is the radiobiology and pharmacology research to improve outcomes in glioblastoma?

Abstract

Personalized medicine has been helpful for drug development in diseases with single and relatively stable gene mutations. The benefit for complex solid tumours with heterogeneous and changing genetic profiles is less clear. Whether it is efficient to continue diverting resources from combined biological and pharmacological approaches to trial new and existing genetic ‘targeted therapies’ for brain tumours is unknown but of developing concern in resource constrained environments.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Correspondence to Jennifer Martin.

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Fay, M., Head, R. & Martin, J. Where is the radiobiology and pharmacology research to improve outcomes in glioblastoma?. J Neurooncol 124, 1–3 (2015). https://doi.org/10.1007/s11060-015-1816-z

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Keywords

  • Imatinib
  • Valproic Acid
  • Glioblastoma Multiforme
  • BRAF Inhibitor
  • Interstitial Concentration