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Familial gliomas: cases in two pairs of brothers

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Abstract

The majority of gliomas are sporadic in origin. Familial gliomas have been reported, though they are exceptionally rare. Several familial cancer syndromes are associated with autosomal dominant glioma risk, typically with incomplete penetrance. When two siblings are affected in the absence of a known dominantly inherited cancer syndrome, an autosomal recessive condition may be suspected (e.g. constitutional mismatch repair syndrome). We present two separate sets of siblings, one set with low grade gliomas, and the other with high grade gliomas. Histology for all tumors were either oligodendroglioma or had features of oligodendroglioma. Interestingly, there is a nearly identical histopathology and anatomical localization noted in these clinical presentations. For one family, genetic testing and family inquiry have resulted in no identifiable genetic pattern of disease. High-penetrance familial mutations and common low-penetrance susceptibility loci (e.g. single-nucleotide polymorphism (SNPs)) may contribute to familial glioma risk. We present two instances of familial glioma without an identifiable genetic cause. These cases implicate a potential heritable etiology for glioma families in which Mendelian disorders have not been identified. Further investigation should focus on identifying the potential genetic links involved with cases such as the ones presented here.

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References

  1. Sadetzki S, Bruchim R, Oberman B, Armstrong GN et al (2013) Description of selected characteristics of familial glioma patients: results from the Gliogene Consortium. Eur J Cancer 49:1335–1345

    Article  PubMed Central  PubMed  Google Scholar 

  2. McCarthy BJ, Rankin KM, Aldape K, Bondy ML et al (2011) Risk factors for oligodendroglial tumors: a pooled international study. Neuro-Oncology 13(2):242–250

    Article  PubMed Central  PubMed  Google Scholar 

  3. Malmer B, Henriksson R, Gronberg H (2003) Familial brain tumors—genetics or environment? A nationwide cohot study of cancer risk in spouses and first-degree relatives of brain tumor patients. Int J Cancer 106:260–263

    Article  CAS  PubMed  Google Scholar 

  4. Ugonabo I, Bassily N, Beier A, Yeung JT et al (2011) Familail glioblastoma: a case report of glioblastoma in two brothers and review of literature. Surg Neurol Int 2:153

    Article  PubMed Central  PubMed  Google Scholar 

  5. Ilenciakova D, Seinova D, Jindrova J, Babal P (2011) High-grade brain tumors in siblings with biallelic MSH6 mutations. Pediatr Blood Cancer 57:1067–1070

    Article  Google Scholar 

  6. Fountaine T, Lind CR, Law AJ (2006) Primary glioblastomas and anaplastic astrocytoma in a glioma family. J Clin Neurosci 13:497–501

    Article  PubMed  Google Scholar 

  7. Hariharan S, Donahue JE, Garre C, Oringone P et al (2006) Clinicopathologic and genetic analysis of siblints with NF1 and adult-onset gliomas. J Neurol Sci 247:105–108

    Article  PubMed  Google Scholar 

  8. Jenkins RB, Xiao Y, Sicotte H, Decker PA et al (2012) A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendrogial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet 44:1122–1125

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Ostron QT, Gittleman H, Farah P, Ondracek A et al (2013) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro-Oncol 15:1–56

    Article  Google Scholar 

Download references

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The authors have no conflict of interest to disclose.

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Correspondence to Joseph A. Osorio.

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Osorio, J.A., Hervey-Jumper, S.L., Walsh, K.M. et al. Familial gliomas: cases in two pairs of brothers. J Neurooncol 121, 135–140 (2015). https://doi.org/10.1007/s11060-014-1611-2

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  • DOI: https://doi.org/10.1007/s11060-014-1611-2

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