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Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis

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Abstract

Observation following gross-total resection (GTR) for non-anaplastic supratentorial ependymomas is often advocated based on small, retrospective series. The purpose of this study is to perform a population-based analysis to examine outcomes for this rare cohort of low-risk patients. A retrospective analysis was conducted utilizing the Surveillance, Epidemiology and End Results Program of the United States National Cancer Institute. We identified patients with supratentorial non-anaplastic ependymoma who underwent GTR alone or GTR followed by radiation. We identified 92 patients who met these criteria. The median age was 17.5 years (range 1–83) with the majority female (58 %) and white (75 %). Radiotherapy (RT) was delivered in half of patients. The 5-/10-year Kaplan–Meier estimated overall survival (OS) and cause-specific survival (CSS) for the overall cohort was 83.2/71.4 and 84.1/78.0 %, respectively. There was no evidence of decreased CSS (HR 0.52 [0.18–1.51]; p = 0.23) or OS (HR 0.63 [0.25–1.59]; p = 0.33) with the omission of RT on univariate analysis. Age ≥18 years correlated with worse OS (HR 4.01 [1.45–11.11]; p = 0.008) and CSS (HR 2.86 [0.99–8.31]; p = 0.05). RT did not impact outcome for this low-risk cohort of patients. Older age correlates with poor prognosis.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd. Unit 0097, Houston, TX, 77030, USA

    Amol J. Ghia, Anita Mahajan, Pamela K. Allen & Paul D. Brown

  2. Department of Neuro-oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

    Terri S. Armstrong & Mark R. Gilbert

  3. Department of Neurosurgery, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

    Frederick F. Lang Jr.

  4. Department of Family Health, The University of Texas Health Sciences Center School of Nursing, Houston, TX, USA

    Terri S. Armstrong

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  1. Amol J. Ghia
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Correspondence to Amol J. Ghia.

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Ghia, A.J., Mahajan, A., Allen, P.K. et al. Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. J Neurooncol 115, 513–520 (2013). https://doi.org/10.1007/s11060-013-1254-8

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