Abstract
Ionizing radiation is the most recognized risk factor for meningioma in pediatric long-term cancer survivors. Information in this rare setting is exceptional. We report the clinical and cytogenetic findings in a radiation-induced atypical meningioma following treatment for desmoplastic medulloblastoma in a child. This is the second study to describe the cytogenetic aspects on radiation-induced meningiomas in children. Chromosome banding analysis revealed a 46, XX, t(1;3)(p22;q12), del(1)(p?)[8]/46, XX[12]. Loss of chromosome 1p as a consequence of irradiation has been proposed to be more important in the development of secondary meningiomas in adults. Deletions in the short arm of chromosome 1 also appear to be a shared feature in both pediatric cases so far analyzed.
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This research was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP proc.: 2010/15,717–0).
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Brassesco, M.S., Valera, E.T., Neder, L. et al. Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature. J Neurooncol 110, 397–402 (2012). https://doi.org/10.1007/s11060-012-0982-5
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DOI: https://doi.org/10.1007/s11060-012-0982-5