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FABP4 is a candidate marker of cerebellar liponeurocytomas

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Abstract

Cerebellar liponeurocytoma (cLPN) is a very rare central nervous system (CNS) tumour recently recognized as a clinical and pathological entity distinct from medulloblastoma (MB), and included in the WHO classification of CNS tumours under the heading “glioneuronal tumours”. cLPN typically develop in adult age and have a favourable prognosis compared with MB. In this work, we reviewed the clinical and neuroradiological data of two novel cases of adult cLPN diagnosed at our institution; one patient developed distant metastases. We tried to identify novel molecular markers for this malignancy. We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB. These findings suggest cLPN occur as a result of transformation of cerebellar progenitors, which are distinct from cerebellar granule progenitors, and aberrantly differentiate into adipocyte-like tumour cells. They also suggest that analysis of FABP4 expression is of help to differentiate cLPN from MB.

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References

  1. Kleihues P, Chimelli L, Giangaspero F (2000) Cerebellar liponeurocytoma. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 110–111

    Google Scholar 

  2. Kleihues P, Chimelli L, Giangaspero F, Ohgaki H (2007) Cerebellar liponeurocytoma. In: Kleihues P, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC Press, Lyon, pp 110–112

    Google Scholar 

  3. Horstmann S, Perry A, Reifenberger G, Giangaspero F, Huang H, Hara A, Masuoka J, Rainov NG, Bergmann M, Heppner FL, Brandner S, Chimelli L, Montagna N, Jackson T, Davis DG, Markesbery WR, Ellison DW, Weller RO, Taddei GL, Conti R, Del Bigio MR, González-Cámpora R, Radhakrishnan VV, Söylemezoglu F, Uro-Coste E, Qian J, Kleihues P, Ohgaki H (2004) Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathol 14(3):281–289

    Article  PubMed  CAS  Google Scholar 

  4. Chakraborti S, Mahadevan A, Govindan A, Yasha TC, Santosh V, Kovoor JM, Ramamurthi R, Alapatt JP, Hedge T, Shankar SK (2011) Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature. J Neurooncol 103(1):121–127

    Article  PubMed  Google Scholar 

  5. Owler BK, Makeham JM, Shingde M, Besser M (2005) Cerebellar liponeurocytoma. J Clin Neurosci 12:326–329

    Article  PubMed  Google Scholar 

  6. Buccoliero AM, Caldarella A, Bacci S, Gallina P, Taddei A, Di Lorenzo N, Romagnoli P, Taddei GL (2005) Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case. Neuropathology 25(1):77–83

    Article  PubMed  Google Scholar 

  7. Châtillon CE, Guiot MC, Roberge D, Leblanc R (2009) Cerebellar liponeurocytoma with high proliferation index: treatment options. Can J Neurol Sci 36:658–661

    PubMed  Google Scholar 

  8. Limaiem F, Bellil S, Chelly I, Bellil K, Mekni A, Jemel H, Haouet S, Zitouna M, Kchir N (2009) Recurrent cerebellar liponeurocytoma with supratentorial extension. Can J Neurol Sci 36(5):662–665

    PubMed  Google Scholar 

  9. Sharma MC, Agarwal M, Suri A, Gaikwad S, Mukhopadhyay P, Sarkar C (2002) Lipomedulloblastoma in child: a controversial entity. Human Pathol 33(5):564–569

    Article  CAS  Google Scholar 

  10. Aker FV, Ozkara S, Eren P, Peker O, Armagan S, Hakan T (2005) Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol 71:53–59

    Article  PubMed  Google Scholar 

  11. Patel N, Fallah A, Provias J, Jha NK (2009) Cerebellar liponeurocytoma. Can J Surg 52(4):E117–E119

    PubMed  Google Scholar 

  12. Hortobágyi T, Bódi L, Lantos PL (2007) Adult cerebellar liponeurocytoma with predominant pilocytic pattern and myoid differentiation. Neuropathol Appl Neurobiol 33:121–125

    Article  PubMed  Google Scholar 

  13. Jenkinson MD, Bosma JJ, Du Plessis D, Ohgaki H, Kleihues P, Warnke P, Rainov NG (2003) Cerebellar liponeurocytoma with an unusually aggressive clinical course: case report. Neurosurgery 53(6):1425–1427

    Article  PubMed  Google Scholar 

  14. Gross E, Kiechle M, Arnold N (2001) Mutation analysis of p53 in ovarian tumors by DHPLC. J Biochem Biophys Methods 47:73–81

    Article  PubMed  CAS  Google Scholar 

  15. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765–773

    Article  PubMed  CAS  Google Scholar 

  16. Ellison DW, Onilude OE, Lindsey JC, Lusher ME, Weston CL, Taylor RE, Pearson AD, Clifford SC; United Kingdom Children’s Cancer Study Group Brain Tumour Committee (2005) beta-Catenin status predicts a favourable outcome in childhood medulloblastoma: the United Kingdom Children’s Cancer Study Group Brain Tumour Committee. J Clin Oncol 23(31): 7951–7957

    Google Scholar 

  17. Soylemezoglu F, Soffer D, Onol B, Schwechheimer K, Kleihues P (1996) Lipomatous medulloblastoma in adults. a distinct clinicopathological entity. Am J Surg Pathol 20(4):413–418

    Article  PubMed  CAS  Google Scholar 

  18. Goldowitz D, Hamre K (1998) The cells and molecules that make a cerebellum. Trends Neurosci 21:375–382

    Article  PubMed  CAS  Google Scholar 

  19. Salsano E, Croci L, Maderna E, Lupo L, Pollo B, Giordana MT, Consalez GG, Finocchiaro G (2007) Expression of the neurogenic basic helix-loop-helix transcription factor NEUROG1 identifies a subgroup of medulloblastomas not expressing ATOH1. Neuro Oncol 9(3):298–307

    Article  PubMed  CAS  Google Scholar 

  20. Cataltepe O, Arikan MC, Ghelfi E, Karaaslan C, Ozsurekci Y, Dresser K, Li Y, Smith TW, Cataltepe S (2011) Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma. Neuropathol Appl Neurobiol. doi:10.1111/j.1365-2990.2011.01237.x

  21. Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince TA, Kozakewich H, Bischoff J, Cataltepe S (2009) Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J (official publication of the Federation of American Societies for Experimental Biology) 23:3865–3873

    Article  CAS  Google Scholar 

  22. Kawai M, Rosen CJ (2010) PPARγ: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol 6(11):629–636

    Article  PubMed  CAS  Google Scholar 

  23. Ryan KK, Li B, Grayson BE, Matter EK, Woods SC, Seeley RJ (2011) A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med 17(5):623–626

    Article  PubMed  CAS  Google Scholar 

  24. Urbanska K, Pannizzo P, Grabacka M, Croul S, del Valle L, Khalili K, Reiss K (2008) Activation of PPARα inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines. Int J Cancer 123:1015–1024

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Unit of Molecular Neuro-oncology, Fondazione IRCCS C. Besta, Via Celoria 11, 20133, Milan, Italy

    Elena Anghileri, Marica Eoli, Rosina Paterra, Ettore Salsano & Gaetano Finocchiaro

  2. Department of Neurosurgery, Fondazione IRCCS C. Besta, Via Celoria 11, 20133, Milan, Italy

    Paolo Ferroli, Giovanni Tringali & Marco Saini

  3. Unit of Neuropathology, Fondazione IRCCS C. Besta, Via Celoria 11, 20133, Milan, Italy

    Bianca Pollo & Emanuela Maderna

  4. Unit of Neuroradiology, Fondazione IRCCS C. Besta, Via Celoria 11, 20133, Milan, Italy

    Valeria Cuccarini

Authors
  1. Elena Anghileri
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  2. Marica Eoli
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  3. Rosina Paterra
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  4. Paolo Ferroli
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  5. Bianca Pollo
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  6. Valeria Cuccarini
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  7. Emanuela Maderna
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  8. Giovanni Tringali
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  9. Marco Saini
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  10. Ettore Salsano
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  11. Gaetano Finocchiaro
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Correspondence to Elena Anghileri.

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Anghileri, E., Eoli, M., Paterra, R. et al. FABP4 is a candidate marker of cerebellar liponeurocytomas. J Neurooncol 108, 513–519 (2012). https://doi.org/10.1007/s11060-012-0853-0

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  • DOI: https://doi.org/10.1007/s11060-012-0853-0

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