Abstract
Despite recent advances, glioblastoma (GBM) remains incurable but is typically characterized by local tumor recurrence in the brain. Soft tissue metastases from GBM are extremely rare, with only eight reported cases in the literature. It has been postulated that this type of metastases rarely occurs due to inability of tumor cells to survive outside the brain milieu, physical barriers preventing tumor spread, and/or early patient death from this aggressive tumor. Here we present another case of soft tissue metastases that occurred in a young woman with GBM and review the previous literature.
References
Allan RS (2004) Scalp metastasis from glioblastoma. J Neurol Neurosurg Psychiatry 75(4):559
Alvord EC Jr (1976) Why do gliomas not metastasize. Arch Neurol 33(2):73–75
Bouillot-Eimer S, Loiseau H et al (2005) Subcutaneous tumoral seeding from a glioblastoma following stereotactic biopsy: case report and review of the literature. Clin Neuropathol 24(6):247–251
Cervio A, Piedimonte F et al (2001) Bone metastases from secondary glioblastoma multiforme: a case report. J Neurooncol 52(2):141–148
Davis L (1928) Spongioblastoma multiforme of the brain. Ann Surg 87(1):8–14
El-Gindi S, Salama M et al (1973) Metastases of glioblastoma multiforme to cervical lymph nodes. Report of two cases. J Neurosurg 38(5):631–634
Figueroa P, Lupton JR et al (2002) Cutaneous metastasis from an intracranial glioblastoma multiforme. J Am Acad Dermatol 46(2):297–300
Jain N, Mirakhur M et al (2005) Cutaneous metastasis from glioblastoma. Br J Neurosurg 19(1):65–68
Mentrikoski M, Johnson MD et al (2008) Glioblastoma multiforme in skin: a report of 2 cases and review of the literature. Am J Dermatopathol 30(4):381–384
Saad AG, Sachs J et al (2007) Extracranial metastases of glioblastoma in a child: case report and review of the literature. J Pediatr Hematol Oncol 29(3):190–194
Santos AV, Saraiva PF et al (2003) Extracranial metastasis of glioblastoma multiforme. Acta Med Port 16(3):209–211
Vertosick FT Jr, Selker RG (1990) Brain stem and spinal metastases of supratentorial glioblastoma multiforme: a clinical series. Neurosurgery 27(4):516–521 (discussion 521–522)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Armstrong, T.S., Prabhu, S., Aldape, K. et al. A case of soft tissue metastasis from glioblastoma and review of the literature. J Neurooncol 103, 167–172 (2011). https://doi.org/10.1007/s11060-010-0370-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11060-010-0370-y