Skip to main content

Advertisement

SpringerLink
Log in

Optic pathway ganglioglioma with intraventricular cyst

  • Case Report
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Gangliogliomas originating in the optic pathway are rare, with less than 20 cases reported in the literature. Diffuse, bilateral involvement of the entire optico-chiasmatic pathway is exceptional. We report a case of suprasellar ganglioglioma that involved bilaterally the entire pregeniculate optic pathway. The patient presented with visual deficit, nystagmus, papilledema and acute biventricular hydrocephalus secondary to intraventricular cyst that required urgent surgery. Endoscopic fenestration of the tumoral cyst allowed control of hydrocephalus and decompression of the visual pathway. Through microsurgical procedure by pterional approach, partial removal of the tumor and histological diagnosis were accomplished 1 week later. The patient was managed with chemotherapy and radiation therapy. He presents stable residual disease at 4-year follow-up. Embryological origins, histological features, neuroradiological appearance, management and prognosis of optic pathway gangliogliomas are reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Perkins O (1926) Ganglioglioma. Arch Pathol Lab Med 2:11–17

    Google Scholar 

  2. Liu GT, Galetta SL, Rorke LB, Bilaniuk LT, Vojta DD, Molloy PT, Phillips PC, Needle M, Duhaime AC, Sutton LN, Volpe NJ (1996) Gangliogliomas involving the optic chiasm. Neurology 46:1669–1673

    PubMed  CAS  Google Scholar 

  3. Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos MG, Solymosi L, Schramm J (1994) Gangliogliomas clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 57:1497–1502

    Article  PubMed  CAS  Google Scholar 

  4. Hakim R, Loeffler JS, Anthony DC, Black PM (1997) Gangliogliomas in adults. Cancer 79:127–131

    Article  PubMed  CAS  Google Scholar 

  5. Luyken C, Blumcke I, Fimmers R, Urbach H, Wiestler OD, Schramm J (2004) Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer 101:146–155

    Article  PubMed  Google Scholar 

  6. Albayrak R, Albayram S, Port J, Degirmenci B, Acar M, Yucel A (2004) Ganglioglioma of the right optic tract: case report and review of the literature. Magn Reson Imaging 22:1047–1051

    Article  PubMed  Google Scholar 

  7. Sugiyama K, Goishi J, Sogabe T, Uozumi T, Hotta T, Kiya K (1992) Ganglioglioma of the optic pathway: a case report. Surg Neurol 37:22–25

    Article  PubMed  CAS  Google Scholar 

  8. Allen JC, Judkins AR, Rosenblum MK, Biegel JA (2006) Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study. Neuro-Oncology 8:79–82

    Article  PubMed  Google Scholar 

  9. Chilton J, Caughron MR, Kepes JJ (1990) Ganglioglioma of the optic chiasm: case report and review of the literature. Neurosurgery 26:1042–1045

    Article  PubMed  CAS  Google Scholar 

  10. Cogan DG, Poppen JL, Hicks SP (1961) Ganglioneuroma of chiasm and optic nerves. Arch Ophthalmol 65:481–482

    PubMed  CAS  Google Scholar 

  11. Gupta R, Suri V, Arora R, Sharma MC, Mishra S, Singh M, Sarkar C (2009) Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation. Childs Nerv Syst. doi:10.1007/s00381-009-0989-1

  12. Jalali R, Deopujari CE, Bhutani R, Suhas U, Rajasekharan P, Kane SV, Gupta TJ (2008) Suprasellar ganglioglioma with unusual diffuse involvement of the entire optico-chiasmal hypothalamic pathway. Cancer Res Ther 4:140–143

    Article  Google Scholar 

  13. Lowes M, Bojsen-Moller M, Vorre P, Hedegaard O (1978) An evaluation of gliomas of the anterior visual pathways: a 10-year survey. Acta Neurochir (Wien) 43:201–206

    Google Scholar 

  14. Lu WY, Goldman M, Young B, Davis DG (1993) Optic nerve ganglioglioma: case report. J Neurosurg 78:979–982

    Article  PubMed  CAS  Google Scholar 

  15. Meyer P, Eberle MM, Probst A, Tolnay M (2000) Ganglioglioma of optic nerve in neurofibromatosis type 1. Case report and review of the literature. Klin Monbl Augenheilkd 217:55–58

    Article  PubMed  CAS  Google Scholar 

  16. Pant I, Suri V, Chaturvedi S, Dua R, Kanodia AK (2006) Ganglioglioma of the optic chiasma: case report and review of literature. Childs Nerv Syst 22:717–720

    Article  PubMed  Google Scholar 

  17. Sadun F, Hinton DR, Sadun AA (1996) Rapid growth of an optic nerve ganglioglioma in a patient with neurofibromatosis 1. Ophthalmol 103:794–799

    CAS  Google Scholar 

  18. Shuangshoti S, Kirsch E, Bannan P, Fabian VA (2000) Ganglioglioma of the optic chiasm: case report and review of the literature. Am J Neuroradiol 21:1486–1489

    PubMed  CAS  Google Scholar 

  19. Vajramani GV, Dambatta S, Walker M, Grundy PL (2006) Multiple gangliogliomas of the optic pathway. Br J Neurosurg 20:428–430

    Article  PubMed  CAS  Google Scholar 

  20. Parsa CF, Givrad S (2008) Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: grounds for designation as hamartomas. Br J Ophthalmol 92:40–46

    Article  PubMed  CAS  Google Scholar 

  21. Rumana CS, Valadka AB, Contant F (1999) Prognostic factors in supratentorial ganglioglioma. Acta Neurochir (Wien) 141:63–68

    Article  CAS  Google Scholar 

  22. Benitez WI, Glasier CM, Husain M, Angtuaco EJ, Chadduck WM (1990) MR findings in childhood ganglioglioma. J Comput Assist Tomogr 14:712–716

    Article  PubMed  CAS  Google Scholar 

  23. Tamburrini G, Colosimo C, Giangaspero F, Riccardi R, Di Rocco C (2003) Desmoplastic infantile ganglioglioma. Childs Nerv Syst 19:292–297

    Article  PubMed  CAS  Google Scholar 

  24. McCollough DC, Johnson DL (1989) Optic nerve gliomas and other tumors involving the optic nerve and chiasm. In: McLaurin R, Schut J, Venes J (eds) Pediatric neurosurgery and surgery of the developing nervous system, 2nd edn. Saunders, Philadelphia, pp 391–398

    Google Scholar 

  25. Pollack IF, Jakacki RI (2006) Optic gliomas. In: Tonn JC, Westphal M, Rutka JT, Grossman (eds) Neuro-Oncology of CNS Tumors. Springer, Berlin, pp 353–361

  26. Sutton LN, Molloy PT, Sernyak H, Goldwein J, Phillips PL, Rorke LB, Moshang T Jr, Lange B, Packer RJ (1995) Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg 83:583–589

    Article  PubMed  CAS  Google Scholar 

  27. Gururangan S, Fisher MJ, Allen JC, Herndon JE, Quinn JA, Reardon DA, Vredenburgh JJ, Desjardins A, Phillips PC, Watral MA, Krauser JM, Friedman AH, Friedman HS (2007) Temozolomide in children with progressive low-grade glioma. Neuro-Oncology 9:161–168

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

The authors thank Dr Alessandro Della Corte, MD, PhD, for his contribution in the revision of drafts for this manuscript.

Author information

Authors and Affiliations

  1. Department of Pediatric Neurosurgery, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore n.6, 80129, Naples, Italy

    Pietro Spennato, Claudio Ruggiero, Ferdinando Aliberti & Giuseppe Cinalli

  2. Department of Pediatric Neuroradiology, Santobono-Pausilipon Children’s Hospital, Naples, Italy

    Maria Consiglio Buonocore & Anna Nastro

  3. Department of Pathological Anatomy, Santobono-Pausilipon Children’s Hospital, Naples, Italy

    Vittoria D’Onofrio & Delfina Bifani

  4. Department of Neurosurgery, International Neuroscience Institute, Hannover, Germany

    Mario Giordano

Authors
  1. Pietro Spennato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mario Giordano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudio Ruggiero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ferdinando Aliberti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Maria Consiglio Buonocore
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Anna Nastro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vittoria D’Onofrio
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Delfina Bifani
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Giuseppe Cinalli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pietro Spennato.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spennato, P., Giordano, M., Ruggiero, C. et al. Optic pathway ganglioglioma with intraventricular cyst. J Neurooncol 102, 499–508 (2011). https://doi.org/10.1007/s11060-010-0341-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-010-0341-3

Keywords

Search

Navigation