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Meningiomas and neurofibromatosis

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Abstract

Neurofibromatosis type 2 (NF2) is a rare genetic disorder predisposing to multiple benign tumors of the nervous system. Meningiomas occur in about half of NF2 patients, and are often multiple. Patients harboring seemingly isolated multiple meningiomas should be investigated to diagnose NF2 by careful familial history collection, detailed clinical examination (skin lesions and slit lamp examination of the lens), audiovestibular testing, and fine cranio-spinal Magnetic Resonance Imaging. Somatic mosaicism is frequent in NF2 and may explain a mild phenotype as, e.g. isolated multiple meningiomas. Neurofibromatosis type 1 is not associated with an increased risk of meningioma. Whether meningiomas are part of the schwannomatosis tumor phenotype or not remains debated. Meningiomas in NF2 patients are associated with a higher risk of mortality, and their treatment is challenging, but data about natural history of meningiomas in NF2 patients in the literature are sparse. Thus, knowledge of tumor behavior is essential in slow growing tumors like meningiomas, to balance the risk of treatment against the natural history of the disease, and to evaluate the efficiency of alternative therapeutics (radiation therapy or new drugs).

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Authors and Affiliations

  1. INSERM, U674, Paris, 75010, France

    Stéphane Goutagny & Michel Kalamarides

  2. Université Paris 7 – Denis Diderot, Paris, 75010, France

    Stéphane Goutagny & Michel Kalamarides

  3. Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Service de Neurochirurgie, Clichy, 92110, France

    Stéphane Goutagny & Michel Kalamarides

  4. Department of Neurosurgery, APHP, Hôpital Beaujon, 100 Boulevard du General Leclerc, 92110, Clichy, France

    Michel Kalamarides

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  1. Stéphane Goutagny
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Correspondence to Michel Kalamarides.

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Goutagny, S., Kalamarides, M. Meningiomas and neurofibromatosis. J Neurooncol 99, 341–347 (2010). https://doi.org/10.1007/s11060-010-0339-x

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  • DOI: https://doi.org/10.1007/s11060-010-0339-x

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