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Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population

Journal of Neuro-Oncology volume 102, pages 347–352 (2011)Cite this article

Abstract

Matrix metalloproteinase-1 (MMP-1) is known to be involved in the pathogenesis of glioma. It damages the extra-cellular matrix to produce invasiveness in cancer tissue, and hence has a direct effect in cancer invasion. The study aims to explore the association of single nucleotide polymorphism of -1607 MMP-1 gene with susceptibility to glioblastoma multiforme (GBM) in northern Indian subjects. One hundred and ten GBM patients and 150 healthy controls were included in this study. 1607 MMP-1 gene was studied by PCR–RFLP; different genotypes being combinations of 1G and 2G allele (1G/1G, 1G/2G and 2G/2G). 2G/2G genotype was significantly associated with GBM patients (OR, 2.24; P = 0.016; 95% CI, 1.16–4.30) as compared to controls. Prevalence of the 2G allele of -1607 MMP-1 polymorphism was significantly greater in GBM patients as compared to controls (62.3 vs 48.3%, OR, 1.76; P = 0.002; 95% CI, 1.23–2.52). This study suggests that the 2G/2G genotype and 2G allele of -1607 MMP-1 polymorphism are associated with an increased susceptibility for developing GBM.

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Acknowledgment

The authors express their gratitude and are cordially thankful to Kishan K. Nyati and Hariom Singh for their kind co-operation and support.

Conflict of interest

The authors declare that they have no conflict of interest.

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Affiliations

  1. Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India

    Nitin Malik, Raj Kumar, Priyanka Kawal & Arun Srivastava

  2. Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India

    Kashi N. Prasad

  3. Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, 110029, India

    Ashok K. Mahapatra

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  1. Nitin Malik
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  2. Raj Kumar
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  3. Kashi N. Prasad
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Correspondence to Raj Kumar.

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Malik, N., Kumar, R., Prasad, K.N. et al. Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population. J Neurooncol 102, 347–352 (2011). https://doi.org/10.1007/s11060-010-0337-z

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  • DOI: https://doi.org/10.1007/s11060-010-0337-z

Keywords

  • Glioblastoma multiforme (GBM)
  • Glioma
  • Matrix metalloproteinase-1
  • Polymorphism