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Quantification of dispersion of Gd-DTPA from the initial area of enhancement into the peritumoral zone of edema in brain tumors

Journal of Neuro-Oncology volume 94, Article number: 399 (2009) Cite this article

Abstract

To evaluate Gd-DTPA contrast enhancement of brain tumors over time and to describe the dispersion of contrast into the zone of peritumoral edema. We performed MR imaging with a dose of 0.4 mmol Gd-DTPA/kg on eleven patients diagnosed with 5 different supratentorial tumors. MR imaging was done at five intervals between 5 min and 6 h. The change in zone of enhancement was measured for each time point, and a linear measurement was made of the furthest dispersion of contrast from the original volume of enhancement. An increase in the zone of enhancement over time was seen for all tumors; the average increase in volume of contrast was 14.76 ± 3.35 cm3 (mean ± standard deviation). The largest changes in the zone of contrast enhancement, 18.6 ± 4.63 cm3, were seen in glioblastoma multiforme. The expansion of contrast enhancement assumed the morphology of the surrounding edema. The dispersion of Gd-DTPA over time into the zone of peritumoral edema is a potential source of error in clinical settings when there is a delay between Gd-DTPA injection and scanning.

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Acknowledgment

This work was supported by the Memorial Sloan-Kettering Summer Student Fellowship Program from the National Institutes of Health/National Cancer Institute for the second author.

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Affiliations

  1. Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia

    Igor N. Pronin & Valeri N. Kornienko

  2. Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Kathleen A. McManus, Andrei I. Holodny & Kyung K. Peck

  3. Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Kyung K. Peck

Authors
  1. Igor N. Pronin
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  2. Kathleen A. McManus
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  3. Andrei I. Holodny
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  4. Kyung K. Peck
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  5. Valeri N. Kornienko
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Correspondence to Andrei I. Holodny.

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Pronin, I.N., McManus, K.A., Holodny, A.I. et al. Quantification of dispersion of Gd-DTPA from the initial area of enhancement into the peritumoral zone of edema in brain tumors. J Neurooncol 94, 399 (2009). https://doi.org/10.1007/s11060-009-9872-x

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  • DOI: https://doi.org/10.1007/s11060-009-9872-x

Keywords

  • Brain tumors
  • Gadolinium
  • Neurosurgery
  • Glioma