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A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature

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Abstract

Ependymomas are glial tumours representing approximately 5–10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.

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Acknowledgments

We would like to thank the patient’s parents, who gave consent to perform this research and to clinicians for providing patient’s samples. This work was partially supported by the Lucent Foundation, the Associazione Italiana Ricerca sul Cancro (Italian Cancer Research Association), and the Ricerca Sanitaria Finalizzata Regione Piemonte (grant for health research projects financed by Regione Piemonte, Italy).

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Author notes

  1. Flavio Giordano

    Present address: Department of Neurosurgery, “Anna Meyer” Hospital, Florence, Italy

Authors and Affiliations

  1. Department of Paediatric Haematology/Oncology, University of Turin, Piazza Polonia, 94, 10126, Torino, Italy

    Simona Aschero, Stefano Vallero, Maria E. Basso & Luca Cordero di Montezemolo

  2. Department of Pathology, “Regina Margherita” Children’s Hospital, Turin, Italy

    Isabella Morra & Marco Forni

  3. Department of Genetics and Microbiology, University of Bari, Bari, Italy

    Luciana Impera & Clelia T. Storlazzi

  4. Department of Biological and Clinical Science, University of Turin, Torino, Italy

    Alessandro Sandri

  5. Oncology Unit, “Bambino Gesù” Paediatric Hospital, Rome, Italy

    Paola Fidani & Maria A. De Ioris

Authors
  1. Simona Aschero
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  2. Stefano Vallero
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  3. Isabella Morra
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  4. Luciana Impera
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  5. Marco Forni
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  6. Alessandro Sandri
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  7. Maria E. Basso
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  8. Clelia T. Storlazzi
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  9. Flavio Giordano
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  11. Maria A. De Ioris
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  12. Luca Cordero di Montezemolo
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Corresponding author

Correspondence to Simona Aschero.

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Aschero, S., Vallero, S., Morra, I. et al. A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature. J Neurooncol 99, 141–146 (2010). https://doi.org/10.1007/s11060-009-0108-x

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  • DOI: https://doi.org/10.1007/s11060-009-0108-x

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