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A case with coincidental diagnosis of primary central nervous system lymphoma and lymph node sarcoidosis

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Abstract

Primary central nervous system lymphoma (PCNSL) is rare. Clinical and histological differential diagnosis of systemic lymphoma and sarcoidosis continues to be a challenge. The first case report in the German and English literature of PCNSL and synchronous sarcoidosis is presented. Synchronous mediastinal lymphadenopathy suggestive of non-Hodgkin’s lymphoma (NHL) or sarcoidosis was noted. Both conditions require alternative therapeutic and prognostic considerations to PCNSL. A regime of intrathecal and adjuvant systemic chemotherapy led to transient clinical improvement prior to the patient’s demise through overwhelming sepsis and multiorgan failure. Post mortem findings confirmed synchronous PCNSL with mediastinal lymph node sarcoidosis.

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Acknowledgements

We thank Dr Hischam Taha, Derriford Hospital, Plymouth, UK, for carefully reviewing the manuscript.

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Authors and Affiliations

  1. Department of Neurology, Friedrich-Schiller-University, Erlanger Allee 101, 07740, Jena, Germany

    Eva J. Greiner, Otto W. Witte & Albrecht Günther

  2. Department of Internal Medicine II, Friedrich-Schiller-University, Jena, Germany

    Lars-Olof Mügge

  3. Department of Neuropathology, Friedrich-Schiller-University, Jena, Germany

    Bernd F. M. Romeike

  4. Laboratory for Cytology, Hannover, Germany

    Theodoros Topalidis

  5. Department of Pathology, Friedrich-Schiller-University, Jena, Germany

    Bernhard Theis

  6. Department of Neuroradiology, Friedrich-Schiller-University, Jena, Germany

    Andreas Ragoschke-Schumm

Authors
  1. Eva J. Greiner
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  2. Lars-Olof Mügge
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  3. Bernd F. M. Romeike
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  4. Theodoros Topalidis
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  5. Bernhard Theis
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  6. Andreas Ragoschke-Schumm
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  7. Otto W. Witte
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  8. Albrecht Günther
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Corresponding author

Correspondence to Eva J. Greiner.

Additional information

E.J. Greiner and L.-O. Mügge share first authorship.

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Greiner, E.J., Mügge, LO., Romeike, B.F.M. et al. A case with coincidental diagnosis of primary central nervous system lymphoma and lymph node sarcoidosis. J Neurooncol 99, 129–134 (2010). https://doi.org/10.1007/s11060-009-0101-4

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  • DOI: https://doi.org/10.1007/s11060-009-0101-4

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