Abstract
We report a case of fever of unknown origin in an immunocompetent patient as the first manifestation of primary central nervous lymphoma. To our knowledge this is the first reported case in the literature of this association. We recommend brain imaging to be considered in patients presenting with fever of unknown origin and no apparent diagnosis after extensive investigation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Eichler AF, Batchelor TT (2006) Primary central nervous system lymphoma presentation, diagnosis and staging. Neurosurg Focus 21(5):E15. doi:10.3171/foc.2006.21.5.16
Batchelor T, Loefflers JS (2006) Primary CNS lymphoma. J Clin Oncol 24(8):1281–1288. doi:10.1200/JCO.2005.04.8819
Hochberg FH, Miller DC (1998) Primary central nervous lymphoma. Neurosurgery 68(6):835–853
Helle TL, Britt RH, Colby TV (1984) Primary lymphoma of the central nervous system. Clinicopathological study of experience at Stanford. J Neurosurg 60:94–103
Fine HA, Mayer RJ (1993) Primary central nervous system lymphoma. Ann Intern Med 199:1093–1104
Schabet M (1999) Epidemiology of primary CNS lymphoma. J Neurooncol 43(3):199–201. doi:10.1023/A:1006290032052
Braus DF, Schwechheimer K, Muller-Mermelink MK, Schwarzkopf G, Volk B, Mundinger F (1992) Primary cerebral malignant non-Hodgkin’s lymphomas: a retrospective clinical study. J Neurol 239:117–124. doi:10.1007/BF00833908
Herrlinger U, Schabet M, Clemens M, Kortmann RD, Petersen D, Will BE et al (1998) Clinical presentation and therapeutic outcome in 26 patients with primary CNS lymphoma. Acta Neurol Scand 97:257–264
Shenkier TN (2005) Unusual variants of primary central nervous system lymphoma. Hematol Oncol Clin North Am 19(4):651–664
Henry JM, Meffner RR Jr, Dillard SM, Earle KM, Davis RL (1974) Primary malignant lymphomas of the central nervous system. Cancer 34:1293–1302. doi:10.1002/1097-0142(197410)34:4<1293::AID-CNCR2820340441>3.0.CO;2-P
Grote TH, Grosh WW, List AF, Wiley R, Cousar JB, Johnson DM (1989) Primary lymphoma of the central nervous system. A report of 20 cases and a review of the literature. Am J Clin Oncol 12:93–100. doi:10.1097/00000421-198904000-00001
Hayakawa et al (1999) Primary central nervous system lymphoma: from clinical presentation to diagnosis. J Neurooncol 43:3
Shiach Cr et al (1984) Pyrexia of undetermined origin, Diarrhea, and primary cerebral lymphoma associated with acquired immunodeficiency. BMJ 288:449–450
Hirschmann JV (1997) Fever of unknown origin in adults. Clin Infect Dis 24:291–300
Mock DJ et al (1993) Angiotropic lymphoma manifested by fever and painful swollen legs. South Med J 86(12):1432–1435. doi:10.1097/00007611-199312000-00028
Ziedman et al (2004) Fulminant intravascular lymphoma presenting as fever of unknown origin. Leuk Lymphoma 45(8):1691–1693. doi:10.1080/10428190410001683750
Hoshino A et al (2004) Usefulness of FDG-PET to diagnose intravascular lymphomatosis presenting as fever of unknown origin. Am J Hematol 76(3):236–239. doi:10.1002/ajh.20099
Casallo Blanco S et al (2006) Colon lymphoma as a cause of fever of unknown origin. Med Intern 23(8):379–381
Rita E et al (2001) Pituitary lymphoma presenting as fever of unknown origin. J Clin Endocrinol Metab 86:1470–1476
Acknowledgement
We are indebted to Prof. Mohammed Harakati, Dr. Ali Hajeer, Dr. Neville Russell, Dr. David R. Anderson and Mr. Shaheed Henderson for their review, and to Jamila Meyer for her efforts in typing this manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Salih, S.B., Saeed, A.B., Alzahrani, M. et al. Primary CNS lymphoma presenting as fever of unknown origin. J Neurooncol 93, 401–404 (2009). https://doi.org/10.1007/s11060-008-9777-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11060-008-9777-0