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Rapid growth of primary cerebral fibrosarcoma with conversion to glioblastoma at second recurrence

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Abstract

We present a case of de novo fibrosarcoma in a 43-year-old male, with MRI documented evolution from a 5 mm hyperintense area to 5 cm tumor mass in a 12-month period. The diagnosis of low-grade fibrosarcoma was established by three experienced neuropathologists. The patient underwent gross total resection with adjuvant fractionated conformal radiotherapy. Following first recurrence 3 months later, the patient was reoperated and stereotactic radiosurgery of a residual tumor was performed thereafter. The pathological diagnosis was similar, but with additional extensive radiation effects. Six months later the patient underwent aggressive surgical resection for second recurrence. The pathological diagnosis was WHO grade IV glioblastoma. The etiology of this highly unusual progression from primary mesenchymal neoplasm to high-grade glioma is discussed.

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Abbreviations

CT:

Computerized tomography

FLAIR:

Fluid attenuated inversion recovery

MRI:

Magnetic resonance imaging

IDL:

Isodose line

Gy:

Gray

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Acknowledgment

The authors wish to thank Shifra Fraifeld, a research associate in the Department of Neurosurgery, for her editorial assistance with the preparation of this manuscript.

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Author notes

  1. Amos Olufemi Adeleye

    Present address: Division of Neurological Surgery, Department of Surgery, College of Medicine – University of Ibadan and University College Hospital, Ibadan, Nigeria

Authors and Affiliations

  1. Department of Neurosurgery, Hadassah – Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel

    Amos Olufemi Adeleye, Felix Umansky & Yigal Shoshan

  2. Department of Pathology, Hadassah – Hebrew University Medical Center, Jerusalem, Israel

    Yakov Fellig

Authors
  1. Amos Olufemi Adeleye
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  2. Yakov Fellig
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  3. Felix Umansky
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  4. Yigal Shoshan
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Corresponding author

Correspondence to Yigal Shoshan.

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Adeleye, A.O., Fellig, Y., Umansky, F. et al. Rapid growth of primary cerebral fibrosarcoma with conversion to glioblastoma at second recurrence. J Neurooncol 92, 233–238 (2009). https://doi.org/10.1007/s11060-008-9756-5

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  • DOI: https://doi.org/10.1007/s11060-008-9756-5

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