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WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil

  • Laboratory Investigation - Human/Animal Tissue
  • Published:
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Abstract

Werner syndrome (WS) is a premature aging disorder characterized by early onset of symptoms related to normal aging and by a high predisposition to various types of cancer, including gliomas. WS is caused by inherited recessive mutations in the WRN gene, which encodes a helicase considered a caretaker of the genome. Aiming to study the role of WRN Cys1367Arg in glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of this single nucleotide polymorphism in 94 glioma patients and 100 healthy subjects. Comparisons of genotype distributions and allele frequencies did not reveal any significant difference between the groups. Overall and disease-free survival rates were calculated, but no statistically significant difference was observed. Our data suggest that WRN Cys1367Arg SNP is not involved either in susceptibility to developing gliomas or in patient survival, at least in the Brazilian population.

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Acknowledgements

We thank Márcio Rogério Penha and Vanderci Massaro de Oliveira for technical support. Research supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Financiadora de Estudos e Projetos (FINEP CT-INFRA/FADESP) (Grant number: 1017-01). R. R. Burbano was the recipient of a PQ-2 fellowship (number 308256/2006-9) from CNPq.

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Authors and Affiliations

  1. Human Genetics Laboratory, Federal University of Piauí, Av. São Sebastião 2819, 64202-020, Parnaíba, PI, Brazil

    Giovanny R. Pinto & France K. N. Yoshioka

  2. Oncogenetics Laboratory, Department of Medical Genetics, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP, Brazil

    Giovanny R. Pinto & Cacilda Casartelli

  3. Department of Neurosurgery, Pio XII Foundation – Cancer Hospital of Barretos, Av. Antenor Duarte Villela 1331, 14784-400, Barretos, SP, Brazil

    Carlos A. Clara, Marcelo J. Santos & José R. W. Almeida

  4. Human Cytogenetics Laboratory, Federal University of Pará, R. Augusto Corrêa 01, 66075-110, Belém, PA, Brazil

    Rommel R. Burbano

  5. Molecular Oncogenetics Laboratory, Research Unit, University Hospital La Paz, Paseo Castellana 261, 28046, Madrid, Spain

    Juan A. Rey

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  1. Giovanny R. Pinto
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  2. France K. N. Yoshioka
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Correspondence to Giovanny R. Pinto.

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Pinto, G.R., Yoshioka, F.K.N., Clara, C.A. et al. WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil. J Neurooncol 90, 253–258 (2008). https://doi.org/10.1007/s11060-008-9664-8

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  • DOI: https://doi.org/10.1007/s11060-008-9664-8

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