Abstract
Brain metastases are a common occurrence and a major cause of mortality in non-small-cell lung cancer, with few systemic treatment options. Although targeting epidermal growth factor receptor-associated tyrosine kinase with erlotinib and gefitinib results in durable responses in some patients, the activity of these drugs against brain metastases has been poorly documented. In particular, few reports have so far reported the activity of erlotinib in this setting. Here we report the case of a male Italian smoker with an adeno-carcinoma of the lung whose lung cancer and brain metastases have both responded to erlotinib.
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References
Schuette W (2004) Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer 45(Suppl. 2):S253–S257
Shaw E, Scott C, Souhami L et al (1996) Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: Initial report of radiation therapy oncology group protocol (90–05). Int J Radiat Oncol Biol Phys 34(3):647–654
Sequist LV, Bell DW, Lynch TJ, Haber DA (2007) Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Orthod 25(5):587–595
Pao W, Miller VA (2005) Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions. J Clin Orthod 23(11):2556–2568
Ceresoli GL, Cappuzzo F, Gregorc V et al (2004) Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial. Ann Oncol 15(7):1042–1047
Rosell R, Taron M, Sanchez JJ et al (2007) Setting the benchmark for tailoring treatment with EGFR tyrosine kinase inhibitors. Future Oncol 3:277–283
Fekrazad MH, Ravindranathan M, Jones DV (2007) Response of intracranial metastases to Erlotinib therapy. J Clin Oncol 31:5024–5026
Von Pawel J, Wagner H, Duell T, Poellinger B (2008) Erlotinib in patients with previously irradiated, recurrent brain metastases from non-small cell lung cancer: two case report. Onkologie 31(3):123–126
Gounant V, Wislez M, Poulot V et al (2007) Subsequent brain metastasis responses to epidermal growth factor receptor tyrosine kinase inhibitors in a patient with non-small-cell lung cancer. Lung Cancer 58(3):425–428
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Altavilla, G., Arrigo, C., Santarpia, M.C. et al. Erlotinib therapy in a patient with non-small-cell lung cancer and brain metastases. J Neurooncol 90, 31–33 (2008). https://doi.org/10.1007/s11060-008-9623-4
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DOI: https://doi.org/10.1007/s11060-008-9623-4