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Long-term outcome of conventional radiation therapy for central neurocytoma

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Abstract

The authors report the long-term outcome of conventional radiation therapy (RT) in six cases of central neurocytoma (CN). Between 1985 and 1992, six patients were treated with RT for residual tumors or for prevention of recurrence after surgery. The median follow-up period of radiological and clinical status were 171 (range: 128–229) and 202 months (range: 165–227), respectively. Tumors disappeared in three and reduced in three patients at the last follow-up. One-mortality case due to radiation necrosis and one radiation-induced malignancy occurred. White matter degeneration and cortical atrophy were noticed with slow progression of performance deterioration in two patients. Conventional RT seemed to effectively control residual CN after surgery. However, more sophisticated radiation techniques should be applied to minimize the late sequela.

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Acknowledgments

This work was partially supported by a grant from Cancer Research Institute of Seoul National University and Clinical Research institute of Seoul National University Hospital.

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Authors and Affiliations

  1. Department of Neurosurgery, Seoul National University College of Medicine, Cancer Research Center, Seoul National University, Clinical Research Institute, Seoul National University Hospital, 28 Yeungeun-dong, Jongno-gu, Seoul, 110-744, Korea

    Sun Ha Paek, Jung-Ho Han, Jin Wook Kim, Chul-Kee Park, Hee-Won Jung & Dong Gyu Kim

  2. Department of Pathology, Seoul National University College of Medicine, Seoul National University, Clinical Research Institute, Seoul National University Hospital, 28 Yeungeun-dong, Jongno-gu, Seoul, 110-744, Korea

    Sung-Hye Park

  3. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University, Clinical Research Institute, Seoul National University Hospital, 28 Yeungeun-dong, Jongno-gu, Seoul, 110-744, Korea

    Il Han Kim

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  1. Sun Ha Paek
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  2. Jung-Ho Han
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  4. Chul-Kee Park
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  7. Il Han Kim
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  8. Dong Gyu Kim
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Correspondence to Dong Gyu Kim.

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Paek, S.H., Han, JH., Kim, J.W. et al. Long-term outcome of conventional radiation therapy for central neurocytoma. J Neurooncol 90, 25–30 (2008). https://doi.org/10.1007/s11060-008-9622-5

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  • DOI: https://doi.org/10.1007/s11060-008-9622-5

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