Skip to main content
SpringerLink
Log in

Meningeal Castleman’s disease with multifocal involvement: a case report and review of literature

  • Clinical - patient Studies
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Castleman’s disease is an uncommon lymphoproliferative disorder characterized by lymph node enlargement, hyperplasia of lymphoid follicles surrounded by mature lymphocytes, and capillary proliferation with endothelial hyperplasia. Although intracranial location is very uncommon, it should be considered in the differential diagnosis of meningeal tumors. We describe a new case appearing as two solid extraaxial masses simulating meningiomas. This multifocal meningeal involvement can be considered as an exceptional form of presentation of intracranial Castleman’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Castleman B, Towne VW (1954) Hyperplasia of mediastinal lymph node. Case records of the Massachusetts General Hospital. Case 40011. N Engl J Med 250:26–30

    Google Scholar 

  2. Castleman B, Iverson L, Menendez VP (1956) Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 9:822–830

    Article  PubMed  CAS  Google Scholar 

  3. Keller AR, Hochholzer L, Castleman B (1972) Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 29:670–683

    Article  PubMed  CAS  Google Scholar 

  4. Frizzera G, Banks PM, Massarelli G, Rosau J (1983) A systemic lymphoproliferative disease with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 7:211–231

    Article  PubMed  CAS  Google Scholar 

  5. Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H (1985) Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol 16:162–172

    Article  PubMed  CAS  Google Scholar 

  6. Frizzera G (1985) Castleman’s disease: more questions than answers. Hum Pathol 16:202–205

    Article  PubMed  CAS  Google Scholar 

  7. Karcher DS, Pearson CE, Butler WM, Hurwitz MA, Cassel PF (1982) Giant lymph node hyperplasia involving the thymus with associated nephritic syndrome and myelofibrosis. Am J Clin Pathol 77:100–104

    PubMed  CAS  Google Scholar 

  8. Lacombe MJ, Poirier J, Caron JP (1983) Intracranial lesion resembling giant lymph node hyperplasia. Am J Clin Pathol 80:721–723

    PubMed  CAS  Google Scholar 

  9. Severson GS, Harrington DS, Weisenburger DD, McComb RD, Casey JH, Gelber BR, Varet B, Abelanet R, Rappaport HH (1988) Castleman’s disease of the leptomeninges. Report of three cases. J Neurosurg 69:283–286

    PubMed  CAS  Google Scholar 

  10. Gianaris PG, Leestma JE, Cerullo LJ, Butler A (1989) Castleman’s disease manifesting in the central nervous system: case report with immunological studies. Neurosurgery 24:608–613

    Article  PubMed  CAS  Google Scholar 

  11. Gulati P, Sun NC, Herman BK, Said JW, Cornford ME (1998) Isolated leptomeningeal Castleman’s disease with viral particles in the follicular dendritic cells. Arch Pathol Lab Med 122:1026–1029

    PubMed  CAS  Google Scholar 

  12. Hashimoto H, Iida J, Hironaka Y, Sakaki T (1999) Intracranial Castleman’s disease of solitary form. Case report. J Neurosurg 90:563–566

    Article  PubMed  CAS  Google Scholar 

  13. Cummings TJ, Gonz JZ, Friedman AH, McLendon RE (2000) Castleman´s disease confined to the leptomeninges. Ann Clin Lab Sci 30:278–282

    PubMed  CAS  Google Scholar 

  14. Ropponen KM, Kankkunen JP, Ronkainen A, Vihavainen M, Alafuzoff I (2002) Castleman’s disease of the leptomeninges: immunohistochemical findings in 2 cases. Clin Neuropathol 21:278–283

    PubMed  CAS  Google Scholar 

  15. Sotrel A, Castellano-Sanchez AA, Prusmack C, Birchansky S, Brathwaite C, Ragheb J (2003) Castleman’s disease in a child presenting with a partly mineralized solitary meningeal mass. Pediatr Neurosurg 38:232–237

    Article  PubMed  Google Scholar 

  16. Delmont E, Lonjon M, Michiels JF, Chanalet S, Bourg V, Xerri L, Bondiau PY, Lebrun C (2003) Castleman’s disease located in the central nervous system. Rev Neurol (Paris) 159:581–585

    CAS  Google Scholar 

  17. Ribeiro LT, Simao GN, Matos AL, Carlotti CG Jr, Colli BO, Neder L, Ribeiro-Silva A, de Castro M, Rego E, Santos AC (2004) Intracranial Castleman’s disease presenting as hypopituitarism. Neuroradiology 46:830–833

    Article  PubMed  CAS  Google Scholar 

  18. Matsumura K, Nakasu S, Tanaka T, Nioka H, Matsuda M (2005) Intracranial localized Castleman’s disease. Case report. Neurol Med Chir (Tokyo) 45:59–65

    Article  Google Scholar 

  19. Mallik AA, Kathchy KC, Clotan N (2007) Solitary intracranial Castleman’s disease, plasma cell variant: a case report. Med Princ Pract 16:226–229

    Article  PubMed  CAS  Google Scholar 

  20. McCarty MJ, Vukelja SJ, Banks PM, Weiss RB (1995) Angiofollicular lymph node hyperplasia (Castleman’s disease). Cancer Treat Rev 21:291–310

    Article  PubMed  CAS  Google Scholar 

  21. Kepes JJ, Chen WY, Connors MH, Vogel FS (1988) “Chordoid” meningeal tumors in young individuals with peritumoral lymphoplasmacellular infiltrates causing systemic manifestations of the Castleman syndrome. A report of seven cases. Cancer 62:391–406

    Article  PubMed  CAS  Google Scholar 

  22. Tu P, Giannini C, Judkins AR, Schwalb JM, Burack R, O’Neill BP, Yachnis AT, Burger PC, Scheithauer BW, Perry A (2005) Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma. J Clin Oncol 23:5718–5727

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Hospital Central de la Defensa “Gomez Ulla”, Madrid, Spain

    Santiago Coca & Miguel Angel Saez

  2. Department of Pathology, Hospital Puerta de Hierro, Madrid, Spain

    Isabel Salas

  3. Department of Functional Neurosurgery, Hospital Rúber Internacional, Madrid, Spain

    Roberto Martínez

  4. Department of Neurosurgery, Hospital Puerta de Hierro, Autonomous University, San Martín de Porres, 4, 28035, Madrid, Spain

    Jesús Vaquero

Authors
  1. Santiago Coca
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabel Salas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roberto Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Miguel Angel Saez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jesús Vaquero
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jesús Vaquero.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coca, S., Salas, I., Martínez, R. et al. Meningeal Castleman’s disease with multifocal involvement: a case report and review of literature. J Neurooncol 88, 37–41 (2008). https://doi.org/10.1007/s11060-008-9528-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-008-9528-2

Keywords

Search

Navigation