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A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT

Journal of Neuro-Oncology volume 84, pages 185–188 (2007)Cite this article

Abstract

Lhermitte-Duclos Disease (LDD) is a rare cerebellar lesion that has long been controversial as to whether the entity is a hamartoma, a malformation, or a neoplasm. Recent advances in metabolic imaging and molecular biology have unveiled biological features of LDD and a close relationship between LDD and Cowden disease. Adult onset LDD is now considered identical to Cowden disease in a US guideline. We present a case of LDD, in which high fluorodeoxy glucose (FDG) uptake was shown on PET/CT. We performed dual time point scans, in which a delayed scan exhibited more intense FDG uptake by the hamartomatous lesion than an early scan. We must remain aware of the possibility of LDD when intense accumulation is observed in a cerebellar lesion on FDG-PET/CT imaging.

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Affiliations

  1. Department of Radiology, Saiseikai Matsusaka General Hospital, Matsusaka, Japan

    Toshio Nakagawa, Mikiyoshi Kato & Naohiro Terada

  2. Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Masayuki Maeda & Kan Takeda

  3. Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Japan

    Shigetoshi Shimizu & Yoshito Morooka

  4. Department of Clinical Pathology, Saiseikai Matsusaka General Hospital, Matsusaka, Japan

    Hiroshi Nakano

Authors
  1. Toshio Nakagawa
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  2. Masayuki Maeda
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  3. Mikiyoshi Kato
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  4. Naohiro Terada
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  5. Shigetoshi Shimizu
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  6. Yoshito Morooka
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  7. Hiroshi Nakano
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  8. Kan Takeda
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Corresponding author

Correspondence to Masayuki Maeda.

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Nakagawa, T., Maeda, M., Kato, M. et al. A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT. J Neurooncol 84, 185–188 (2007). https://doi.org/10.1007/s11060-007-9355-x

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  • DOI: https://doi.org/10.1007/s11060-007-9355-x

Keywords

  • Lhermitte-Duclos disease
  • Cowden disease
  • F-18 fluorodeoxy glucose (FDG)
  • Positron emission tomography/computed tomography (PET/CT)
  • Dual time point
  • Delayed scan