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Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

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Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

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  1. Stupp R, Dietrich P-Y, Ostermann Kraljevic S et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20:1375–1382

    Article  PubMed  CAS  Google Scholar 

  2. Stupp R, Mason WP, van den Bent M et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Eng J Med 352:987–996

    Article  CAS  Google Scholar 

  3. Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD (2003) Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97:2262–2266

    Article  PubMed  CAS  Google Scholar 

  4. Curran WJ Jr, Scott CB, Horton J et al (1993) Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials. J Natl Cancer Inst 85:704–710

    Article  PubMed  Google Scholar 

  5. DeAngelis LM (2001) Brain tumors. N Eng J Med 344:114–123

    Article  CAS  Google Scholar 

  6. Stewart LA (2002) Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual data from 12 randomized trials. Lancet 359:1011–1018

    Article  PubMed  CAS  Google Scholar 

  7. de Wit MCY, de Bruin HG, Eijkenboom W, Sillevis-Smitt PAE, van den Bent MJ (2004) Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 63:535–537

    PubMed  Google Scholar 

  8. Cross NE, Glantz MJ (2003) Neurologic complications of radiation therapy. In Wen PY, Glantz MJ (eds) Complications of Systemic Cancer. W.B. Saunders Co., Philadelphia, pp 249–277

    Google Scholar 

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Correspondence to Marc C. Chamberlain.

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Chamberlain, M.C., Glantz, M.J., Chalmers, L. et al. Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neurooncol 82, 81–83 (2007).

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