Abstract
Primary diffuse leptomeningeal oligodendrogliomatosis is a rare malignancy of central nervous system without evidence of a primary intraparenchymal focus. We present a 25-year-old woman with the postmortem diagnosis of primary diffuse leptomeningeal oligodendrogliomatosis. She was paraplegic and had sensory loss at the level of thoracal 8–9 for nearly 15 months. There was no symptom due to increased intracranial pressure. Unexpectedly she died just before biopsy. Autopsy revealed a nodular lesion at the level of thoracal 10 vertebra and diffuse oligodendroglioma throughout the leptomeninges of the brain and spine without intraaxial focus. To our knowledge, this is the first case of primary diffuse leptomeningeal oligodendrogliomatosis causing sudden death in the literature.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cooper IS, Kernohan JW (1951) Heterotopic glial nests in the subarachnoid space: histopathologic characteristcs, mode of origin and reaction to meningeal gliomas. J Neuropathol Exp Neurol 10:16–29
Freeman W (1926) Cortical heterotopia in the pontile meninges. Arch Pathol 2:352–354
Bourne TD, Mandell JW, Matsumoto JA, Lopes MBS (2005) Primary leptomeningeal oligodendroglioma with chromosome 1p deletion: a case report and review of the literature: 95. J Neuropathol Exp Neurol 64 (May):454
Ho KL, Hoschner JA, Wolfe DE (1981) Primary leptomeningeal gliomatosis: symptoms suggestive of meningitis. Arch Neurol 8:662–666
Ng HK, Poon WS (1998) Primary leptomeningeal astrocytoma. Case report. J Neurosurg 88:586–589
Ramsay DA, Goshko V, Nag S (1990) Primary spinal leptmeningeal astrocytoma. Acta Neuropathol 80:338–341
Armao DM, Stone J, Castill M, Mitchell KM, Bouldin TW, Suzuki K (2000) Diffuse leptomenigeal oligodendrogliomatosis: radiologic/pathologic correlation. AJNR Am J Neuroradiol 21:1122–1126
Beck DJK, Russell DS (1942) Oligoendrogliomatosis of the cerebrospinal fluid pathway. Brain 65:332–372
Havlik DM, Becher MW, Nolte KB (2001) Sudden death due to primary diffuse leptomeningeal gliomatosis. J␣Forensic Sci 4:392–395
Rogers LR, Estes ML, Rosenbloom SA, Harrold L (1995) Primary leptomeningeal oligodendroglioma: case report. J␣Neurosurg 36:166–169
Chen R, Mac Donald D, Ramsay D (1995) Primary leptomeningeal oligodendroglioma. Case report. J Neurosurg 83:724–728
Ng HK, Poon WS (1999) Diffuse leptomeningeal gliomatosis with oligodendroglioma. Pathology 31:59–63
Corsten LA, Raja AI, Wagner FC Jr (2001) Primary diffuse leptomeningeal gliomatosis. Br J Neurosurg 15:62–66
Korein J, Feigin I, Shapiro MF (1957) Oligodendrogliomatosis with intracranial hypertension. Neurology 7:589–594
Sumi S, Leffman H (1968) Primary intracranial leptomeningeal glioma with persistent hypoglycorrhachia. J Neurol Neurosur Ps 31:190–194
Hey N, Iglesias JR, Tonsen K, Graef G, Maier Hauff K (1990) Primary leptomeningeal gliomatosis with predominant involvement of the spinal cord. Acta Neurochir (Wien) 102:145–148
Bailey P, Robitaille Y (1985) Primary diffuse leptomeningeal gliomatosis. Can J Neurol Sci 12:278–281
Kitahara M, Katakura R, Wada T, Namiki T, Suzuki J (1985) Diffuse form of primary leptomeningeal gliomatosis. J␣Neurosurg 63:283–287
Dietrich PY, Aapro MS, Rieder A, Pizzolato GP (1993) Primary diffuse leptomeningeal gliomatosis (PDLG): a neoplastic cause of chronic meningitis. J Neuro-oncol 15:275–283
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ozkul, A., Meteoglu, I., Tataroglu, C. et al. Primary diffuse leptomeningeal oligodendrogliomatosis causing sudden death. J Neurooncol 81, 75–79 (2007). https://doi.org/10.1007/s11060-006-9208-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11060-006-9208-z