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Pharmacokinetic study of BSH and BPA in simultaneous use for BNCT

  • Laboratory Investigation
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Summary

In order to improve the effectiveness of boron neutron capture therapy (BNCT) for malignant gliomas, we examined the optimization of the administration of boron compounds in brain tumor animal model. We analyzed the concentration of boron atoms in intracranial C6 glioma -bearing rats using inductively coupled plasma atomic emission spectrometry. Each tumor-bearing rat received one of two different amounts of sodium borocaptate (BSH) and/or 500 mg/kg of boronophenylalanine (BPA) via intraperitoneal injection. We compared the boron concentrations of the tumor, the contralateral normal brain and the blood in rats of 3 different treatment groups (BSH alone, BPA alone and a combination of both BSH and BPA).

Our results show that the tumor boron concentration increased much more than 30 μg/g by the coadministration of both compounds. Additionally, the blood boron concentration remained below 30 μg/g and the boron concentration in the normal brain was low (mean 4.7±1.1 μg/g). Even in comparison with the administration of BPA alone, coadministration of BPA and BSH shows an improved tumor/normal brain ratio of boron concentrations.

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Acknowledgements

This work was supported in part by Grants-in-Aid for Scientific Research (B) (16390422) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, by the Regional Science Promotion Program of the Japan Science and Technology Corporation, and by the “Second-Term Comprehensive 10-Year Strategy for Cancer Control” of the Ministry of Health, Labor and Welfare of Japan to Shin-Ichi Miyatake.

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Authors and Affiliations

  1. Department of Neurosurgery, Osaka Medical College, Takatsuki Osaka, Japan

    Kunio Yokoyama, Shin-Ichi Miyatake, Yoshinaga Kajimoto, Shinji Kawabata, Atsushi Doi & Toshihiko Kuroiwa

  2. Department of Anatomy, Toyama Medical and Pharmaceutical University, Toyama, Japan

    Toshiko Yoshida

  3. Department of Agriculture, Osaka Prefectural University, Sakai, Osaka, Japan

    Tomoyuki Asano & Mitsunori Kirihata

  4. Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Kumatori, Osaka, Japan

    Koji Ono

  5. Department of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, 569-8686, Takatsuki City, Osaka, Japan

    Shin-Ichi Miyatake

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  1. Kunio Yokoyama
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  2. Shin-Ichi Miyatake
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  3. Yoshinaga Kajimoto
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  4. Shinji Kawabata
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  5. Atsushi Doi
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  6. Toshiko Yoshida
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  7. Tomoyuki Asano
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  8. Mitsunori Kirihata
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  9. Koji Ono
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  10. Toshihiko Kuroiwa
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Correspondence to Shin-Ichi Miyatake.

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Yokoyama, K., Miyatake, SI., Kajimoto, Y. et al. Pharmacokinetic study of BSH and BPA in simultaneous use for BNCT. J Neurooncol 78, 227–232 (2006). https://doi.org/10.1007/s11060-005-9099-4

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  • DOI: https://doi.org/10.1007/s11060-005-9099-4

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